Scopus
YÖKSİS DOI Eşleşti
SJR Q1
Chemical characterization, antioxidant, enzyme inhibitory and cytotoxic properties of two geophytes: Crocus pallasii and Cyclamen cilicium
Food Research International · Temmuz 2020
YÖKSİS Kayıtları
Chemical characterization, antioxidant, enzyme inhibitory and cytotoxic properties of two geophytes: Crocus pallasii and Cyclamen cilicium
Food Research International · 2020 SCI-Expanded
Prof. Dr. GÖKHAN ZENGİN →
Chemical characterization, antioxidant, enzyme inhibitory and cytotoxic properties of two geophytes: Crocus pallasii and Cyclamen cilicium
Food Research International · 2020 SCI-Expanded
Prof. Dr. EVREN YILDIZTUGAY →
YÖKSİS Kayıtları — ISSN Eşleşmesi
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Chemical characterization, antioxidant, enzyme inhibitory and cytotoxic properties of two geophytes: Crocus pallasii and Cyclamen cilicium
2020 ISSN: 0963-9969 SCI-Expanded
Prof. Dr. EVREN YILDIZTUGAY →
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Metabolomics profiling and biological properties of root extracts from two Asphodelus species: A. albus and A. aestivus
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2023 ISSN: 0963-9969 SCI-Expanded Q1
Doç. Dr. ALİ SAMET BABAOĞLU →
Makale Bilgileri
ISSN09639969
Yayın TarihiTemmuz 2020
Cilt / Sayfa133
Scopus ID2-s2.0-85080893052
Özet
The Crocus and Cyclamen genus have been reported to possess diverse biological properties. In the present investigation, two geophytes from these genus, namely Crocus pallasi and Cyclamen cilicium have been studied. The in vitro antioxidant, enzyme inhibitory, and cytotoxic effects of the methanol extracts of Crocus pallasii and Cyclamen cilicium aerial and underground parts were investigated. Antioxidant abilities of the extracts were investigated via different antioxidant assays (metal chelating, radical quenching (ABTS and DPPH), reducing power (CUPRAC and FRAP) and phosphomolybdenum). Cholinesterases, amylase, tyrosinase, and glucosidase were used as target enzymes for detecting enzyme inhibitory abilities of the samples. Regarding the cytotoxic abilities, breast cancer cell lines (MDA-MB 231 and MCF-7) and prostate cancer cell lines (DU-145) were used. The flowers extracts of Crocus pallasii and C. cilicium possessed the highest flavonoid content. The highest phenolic content was recorded from C. cilicium root extract (47.62 mg gallic acid equivalent/g extract). Cyclamen cilicium root extract showed significantly (p < 0.05) high radical scavenging (94.28 and 139.60 mg trolox equivalent [TE]/g extract, against DPPH and ABTS radicals, respectively) and reducing potential (173.30 and 109.53 mg TE/g extract, against CUPRAC and FRAP, respectively). The best acetylcholinesterase, glucosidase and tyrosinase inhibition was observed in C. cilicium root (4.46 mg GALAE/g; 15.75 mmol ACAE/g; 136.99 mg KAE/g, respectively). Methanolic extracts of C. pallasii and C. cilicium showed toxicity against breast cancer cell lines. In light of the above findings, C. cilicium might be considered as an interesting candidate in the development of anti-cancer agent coupled with antioxidant properties.
Yazarlar (9)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Mohamad Fawzi Mahomoodally
3
Kouadio Ibrahime Sinan
4
Carene Marie Nancy Picot-Allain
5
Evren Yildiztugay
ORCID: 0000-0002-4675-2027
6
Zoltán Cziáky
7
József Jekő
8
Hammad Saleem
9
Nafees Ahemad
ORCID: 0000-0002-1846-3236
Anahtar Kelimeler
Antioxidant
Bioactive agents
Breast cancer
Crocus
Cyclamen
Prostate cancer
Kurumlar
Duy Tan University
Da Nang Viet Nam
Monash University Malaysia
Bandar Sunway Malaysia
Selçuk Üniversitesi
Selçuklu Turkey
University of Mauritius
Reduit Mauritius
University of Nyíregyháza
Nyíregyháza Hungary
University of Veterinary and Animal Sciences, Lahore
Lahore Pakistan
Scimago Dergi (ISSN Eşleşmesi)
Food Research International
Q1
SJR Skoru1,666
H-Index253
YayıncıElsevier Ltd
ÜlkeUnited Kingdom
Food Science (Q1)
Metrikler
14
Atıf
9
Yazar
6
Anahtar Kelime