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Scopus YÖKSİS DOI Eşleşti SJR Q3

Endoplasmic Reticulum Stress–Mediated Apoptosis Induced by Kaempferol in Colorectal Cancer Cells

Chemistry and Biodiversity · Aralık 2025

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YÖKSİS Kayıtları
Endoplasmic Reticulum Stress–Mediated Apoptosis Induced by Kaempferol in Colorectal Cancer Cells
Chemistry & Biodiversity · 2025 SCI-Expanded
Dr. Öğr. Üyesi KEMAL BAŞ →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 20 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
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Synthesis and Characterization of Copper‐Nanoflowers with the Utilization of Medicinal Plant Extracts for Enhanced Various Enzyme Inhibitory Activities
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Metabolite Profiling by Hyphenated Liquid Chromatographic Mass Spectrometric Technique (HPLC‐DAD‐ESI‐Q‐TOF‐MS/MS) and Neurobiological Potential ofHaplophyllum sahiniiandH. vulcanicumExtracts
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Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.‐Mor
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Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.‐Mor
2023 ISSN: 1612-1872 SCI-Expanded Q3
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Phytochemical Profiling and Biological Activity of Achillea sintenisii Hub.‐Mor
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Makale Bilgileri

Dergi Chemistry and Biodiversity
ISSN16121872
Yayın TarihiAralık 2025
Cilt / Sayfa22
DOI10.1002/cbdv.202403305
Scopus ID2-s2.0-105018341815
Özet Due to its extended latency and high prevalence, human colorectal carcinoma (hCRC) represents an attractive candidate for dietary supplements that have shown remarkable success in tumor treatment. One natural dietary flavonoid, Kaempferol, exhibits numerous pharmacological activities, including antioxidant, antimicrobial, antidiabetic, and anticancer effects. This study aimed to investigate the anti-proliferative effects of Kaempferol and clarify its molecular mechanism on hCRC. High-pressure liquid chromatography (HPLC) and UV–Vis spectroscopy confirmed that the molecular structure of Kaempferol remained stable for up to 48 h. Confocal microscopy further demonstrated that Kaempferol localized in the cytoplasm of cells. The anticancer properties of Kaempferol were evaluated against several human cancer cell lines, including DLD-1 (colorectal carcinoma), A549 (lung cancer), HUH-7 (hepatocarcinoma), HeLa (cervical cancer), and NCI-h295R (adrenal gland cancer), as well as the healthy epithelial cell line CCD-18Co. Kaempferol significantly inhibited the proliferation of DLD-1 cells, with an IC<inf>50</inf> value of 49.55 µM. Kaempferol treatment increased endoplasmic reticulum (ER) stress and apoptosis by 47% (p < 0.001). Kaempferol also modulated the mRNA and protein expression of BcL-2, Bax, Caspase-3, Caspase-9, Caspase-12, Nf-κB, p53, adenomatous polyposis coli (APC), MLH-1, Smad-4, XBP-1, PERK, and ATF6. Molecular docking and 100 ns molecular dynamics simulations revealed a stable binding conformation of Kaempferol within the BcL-2 active site, supported by key hydrogen bonds and hydrophobic interactions with residues such as Asn140 and Tyr199. MM/GBSA free energy and ligand efficiency calculations further confirmed its favorable binding characteristics. Collectively, these findings demonstrate that Kaempferol induces colorectal cancer cell death through ER stress–mediated apoptosis and BcL-2 modulation, positioning it as a promising candidate for further preclinical development.

Yazarlar (4)

1
Serdar Karakurt
2
Hatice Gül Batur
3
Kemal BAS
ORCID: 0000-0003-0881-9793
4
Pinar Siyah
ORCID: 0000-0003-1192-9416

Anahtar Kelimeler

cell migration/colony formation colon cancer cytotoxicity gene/protein expression Kaempferol

Kurumlar

Bahçeşehir Üniversitesi
Istanbul Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Chemistry and Biodiversity
Q3
SJR Skoru0,425
H-Index87
YayıncıWiley-Blackwell
ÜlkeUnited States
Biochemistry (Q3)
Bioengineering (Q3)
Chemistry (miscellaneous) (Q3)
Medicine (miscellaneous) (Q3)
Molecular Biology (Q4)
Molecular Medicine (Q4)
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Metrikler

1
Atıf
4
Yazar
5
Anahtar Kelime

Sistemimizdeki Yazarlar

SK
SERDAR KARAKURT
Prof. Dr.

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