Scopus
Identification of bioactive compounds from Rhaponticoides iconiensis extracts and their bioactivities: An endemic plant to Turkey flora
Journal of Pharmaceutical and Biomedical Analysis · Ekim 2020
Makale Bilgileri
DergiJournal of Pharmaceutical and Biomedical Analysis
Yayın TarihiEkim 2020
Cilt / Sayfa190
Scopus ID2-s2.0-85090011194
Özet
Rhaponticoides iconiensis (Hub.-Mor.) M.V.Agab. & Greuter. (Asteraceae) is an endemic species spread in several small populations in the province of Konya (Turkey). It is critically endangered with an extremely high risk of extinction. Recently, based on the molecular phylogenetic and eco geographical studies on Cardueae-Centaureinae, the genus Rhaponticoides Vaill. was separated from Centaurea L. Antioxidant properties and enzyme inhibition, as well as the phenolic and flavonoid contents, of the methanol (Soxhlet extraction and maceration) and water (infusion) extracts of R. iconiensis leaves, roots, and flower heads were determined. The methanol extracts of R. iconiensis leaves contained the highest amount of phenolic (52.37 and 54.37 mg gallic acid equivalent/g) and flavonoids (74.13 and 80.75 mg rutin equivalent/g). Accordingly, the leaves methanol extracts showed the highest antioxidant potential. Interestingly, the roots methanol extracts were the most potent acetylcholinesterase (4.75 mg galantamine equivalent/g) and butyrylcholinesterase inhibitors (5.26 and 5.14 mg galantamine equivalent/g). The leaves and roots methanol extracts exhibited high α-glucosidase (2.48–3.08 mmol acarbose equivalent/g) and α-amylase (0.17−0.70 mmol acarbose equivalent/g) inhibition. The highest tyrosinase inhibition was recorded for leaves methanol extracts (138.79 and 140.34 mg kojic acid equivalent/g). 87 natural products (including hydroxybenzoic, hydroxycinnamic and acylquinic acids, flavones, flavonols, flavanones and anthocyanins) were unambiguously identified or tentatively annotated in the studied extracts. Findings presented in the present study appraise the bioactivity of R. iconiensis, an understudied species.
Yazarlar (8)
1
Dimitrina Zheleva-Dimitrova
ORCID: 0000-0002-1952-9903
2
Gokhan Zengin
ORCID: 0000-0001-6548-7823
3
Kouadio Ibrahime Sinan
4
Evren Yildiztugay
ORCID: 0000-0002-4675-2027
5
Mohamad Fawzi Mahomoodally
6
Gunes Ak
7
Carene Marie Nancy Picot-Allain
8
Reneta Gevrenova
ORCID: 0000-0002-1254-2419
Anahtar Kelimeler
Antioxidants
Enzyme
Phyto-pharmaceutics
Rhaponticoidesiconiensis
Kurumlar
Duy Tan University
Da Nang Viet Nam
Medical University of Sofia
Sofia Bulgaria
Selçuk Üniversitesi
Selçuklu Turkey
University of Mauritius
Reduit Mauritius
Metrikler
13
Atıf
8
Yazar
4
Anahtar Kelime