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Scopus YÖKSİS DOI Eşleşti SJR Q2

Synthesis of new halo-substituted quinolinecarboxaldehyde-hydrazone derivatives, structural illuminations, investigation of effects on acetylcholinesterase activity and molecular modeling studies

Journal of Molecular Structure · Şubat 2026

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YÖKSİS Kayıtları
Synthesis of new halo-substituted quinolinecarboxaldehyde-hydrazone derivatives, structural illuminations, investigation of effects on acetylcholinesterase activity and molecular modeling studies
Journal of Molecular Structure · 2026 SCI-Expanded
Dr. Öğr. Üyesi NAGİHAN FAYDALI →
Synthesis of New Halo-Substituted Quinolinecarboxaldehyde-Hydrazone Derivatives, Structural Illuminations, Investigation of Effects on Acetylcholinesterase Activity and Molecular Modeling Studies
Journal of Molecular Structure · 2025 SCI-Expanded
Doç. Dr. HANİF ŞİRİNZADE →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 20 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
Synthesis of new halo-substituted quinolinecarboxaldehyde-hydrazone derivatives, structural illuminations, investigation of effects on acetylcholinesterase activity and molecular modeling studies
2026 ISSN: 0022-2860 SCI-Expanded Q2
Dr. Öğr. Üyesi NAGİHAN FAYDALI →
Synthesis, structural characterization, DFT calculations, molecular docking, and antimicrobial activity studies of some new oxazolo[4,5-b]pyridine derivatives
2026 ISSN: 0022-2860 SCI-Expanded Q2
Dr. Öğr. Üyesi NAGİHAN FAYDALI →
Synthesis and spectral properties of pyrene based calix 4 arene
2013 ISSN: 0022-2860 SCI-Expanded
Prof. Dr. ÖZLEM ŞAHİN →
Synthesis enhanced spectroscopic characterization and electrochemical grafting of N 4 aminophenyl aza 18 crown 6 Application of DEPT HETCOR HMBC NMR and X ray photoelectron spectroscopy
2010 ISSN: 00222860 SCI
Prof. Dr. BİLGE TANER →
Amine derivatized calix 4 arenes for sensitive extraction of cupric ion and formation of amine radical cation
2014 ISSN: 00222860 SCI
Prof. Dr. BEGÜM TABAKCI →
Determination of free radical on polycrystal of 4 4 bis chloroacetyl diphenylether An ESR study
2013 ISSN: 00222860 SCI
Prof. Dr. YUSUF CEYLAN →
New tridentate azo azomethines and their copper II complexes Synthesis solvent effect on tautomerism electrochemical and biological studies
2015 ISSN: 0022-2860 SCI
Prof. Dr. HATİCE TÜRK DAĞI →
An EPR study on radiation induced 4 hydroxyphenyl acetic acid polycrystalline
2015 ISSN: 00222860 SSCI
Prof. Dr. YUSUF CEYLAN →
Synthesis of novel chiral Schiff base and amino alcohol derivatives of calix 4 arene and chiral recognition properties
2012 ISSN: 00222860 SCI-Expanded 4 atıf
Prof. Dr. SERKAN ERDEMİR →
Naked eye detection of fluoride and acetate anions by using simple and efficient urea and thiourea based colorimetric sensors
2013 ISSN: 00222860 SCI-Expanded 10 atıf
Prof. Dr. SERKAN ERDEMİR →
A novel Schiff base bearing dopamine groups with tripodal structure Synthesis and its salen salophen bridged Fe Cr III capped complexes
2013 ISSN: 00222860 SCI-Expanded 1 atıf
Prof. Dr. ÖZCAN KOÇYİĞİT →
Naked eye detection of fluoride and acetate anions by using simple and efficient urea and thiourea based colorimetric sensors
2013 ISSN: 00222860 SCI-Expanded 10 atıf
Prof. Dr. ÖZCAN KOÇYİĞİT →
Naked eye detection of fluoride and acetate anions by using simple and efficient urea and thiourea based colorimetric sensors
2013 ISSN: 00222860 SCI-Expanded 13 atıf
Prof. Dr. AHMET OKUDAN →
Synthesis enhanced spectroscopic characterization and electrochemical grafting of N 4 aminophenyl aza 18 crown 6 Application of DEPT HETCOR HMBC NMR and X ray photoelectron spectroscopy
2010 ISSN: 00222860 SCI 5 atıf
Prof. Dr. PERVİN SOYLU →
New tridentate azo azomethines and their copper II complexes Synthesis solvent effect on tautomerism electrochemical and biological studies
2015 ISSN: 00222860 SCI
Prof. Dr. PERVİN SOYLU →
Novel dipodal Schiff base compounds Synthesis characterization and spectroscopic studies
2015 ISSN: 00222860 SCI-Expanded
Doç. Dr. ASLIHAN YILMAZ OBALI →
Nonlinear optical properties spectroscopic studies and structure of 2 hydroxy 3 methoxy N 2 chloro benzyl benzaldehyde imine
2004 ISSN: 00222860 SCI-Expanded 60 atıf
Prof. Dr. ASLI KARAKAŞ →
Nonlinear optical properties of some derivatives of salicylaldimine based ligands
2004 ISSN: 00222860 SCI-Expanded 65 atıf
Prof. Dr. ASLI KARAKAŞ →
The investigation of nonlinear optical properties of N 3 fluorophenyl naphthaldimine
2005 ISSN: 00222860 SCI-Expanded 22 atıf
Prof. Dr. ASLI KARAKAŞ →
Synthesis spectroscopic studies and nonlinear optical behavior of N N bis 2 hydroxy 1 naphthylmethylidene 1 methyl 1 2 diaminoethane N N O O nickel II
2006 ISSN: 00222860 SCI-Expanded 14 atıf
Prof. Dr. ASLI KARAKAŞ →

Makale Bilgileri

Dergi Journal of Molecular Structure
ISSN00222860
Yayın TarihiŞubat 2026
Cilt / Sayfa1351
DOI10.1016/j.molstruc.2025.144337
Scopus ID2-s2.0-105018670661
Özet Acetylcholinesterase (AChE) is a key serum esterase with antiatherosclerotic effects by preventing lipid peroxide oxidation. AChE inhibitors also serve as therapeutic targets for Alzheimer's disease. Newly developed halo-substituted quinolinecarboxaldehyde-hydrazone derivatives (1a–1 s) show significant pharmacological potential due to their broad biological activities. This study evaluated the inhibitory effects of halo-substituted quinolinecarboxaldehyde-hydrazone derivatives on AChE. Acetylcholine esterase IC₅₀ values ranged from 0.143 to 2.015 µM, and Kᵢ values from 0.078 ± 0.030 to 1.074 ± 0.105 µM. Tacrine served as the positive control. Molecular docking studies revealed that compounds 1b and 1k displayed pi-pi interactions (pi-alkyl, pi-pi stacking) and conventional hydrogen bonding. The molecular dynamics simulation study disclosed that compounds 1b and 1k formed stable complexes with the enzyme structure. Moreover, the density functional theory study demonstrated that the active compounds had similar electrical property and reactivity. Together with this, compound 1e was anticipated to exhibit the highest chemical stability among the compounds investigated. All of the compounds were shown to have a high absorption from the gastrointestinal tract and to meet Lipinski's criterion in SwissADME. As a result, it was determined that new halo-substituted quinoline carboxaldehyde-hydrazone derivatives showed strong inhibition effect on this enzyme. In comparison to the reference chemical Tacrine, 1k had the most potent inhibitory activity against AChE. In this context, we anticipate that the findings of this study will aid in identifying the adverse effects of both existing and novel quinolinecarboxaldehyde-hydrazone-based pharmaceutical drugs under development. Additionally, it should be effective in the production of novel AChE inhibitors.

Yazarlar (4)

1
Hanif Şirinzade
2
Nagihan Faydali
ORCID: 0000-0002-8895-1825
3
Muhammed Tilahun Muhammed
ORCID: 0000-0003-0050-5271
4
Esra Dilek

Anahtar Kelimeler

Acetylcholinesterase Alzheimer's disease Enzyme inhibition Quinolinecarboxaldehyde

Kurumlar

Erzincan Binali Yıldırım Üniversitesi
Erzincan Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Süleyman Demirel Üniversitesi
Isparta Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of Molecular Structure
Q2
SJR Skoru0,628
H-Index134
YayıncıElsevier B.V.
ÜlkeNetherlands
Analytical Chemistry (Q2)
Inorganic Chemistry (Q2)
Organic Chemistry (Q2)
Spectroscopy (Q2)
Dergi sayfasına git

Metrikler

4
Atıf
4
Yazar
4
Anahtar Kelime

Sistemimizdeki Yazarlar

HŞ
HANİF ŞİRİNZADE
Doç. Dr.

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