Scopus
🔓 Açık Erişim
Hematological indices in congenital male hypogonadism and the effects of testosterone replacement therapy: a retrospective study
Gulhane Medical Journal · Eylül 2021
Makale Bilgileri
DergiGulhane Medical Journal
Yayın TarihiEylül 2021
Cilt / Sayfa63 · 205-211
Scopus ID2-s2.0-105014780153
Erişim🔓 Açık Erişim
Özet
Aims: Mean platelet volume (MPV), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) are surrogate markers of adverse cardiovascular (CV) outcomes. The aim of this study was to investigate the platelet count, MPV level, PLR, NLR, and the effect of testosterone replacement therapy (TRT) on these parameters in patients with congenital hypogonadotropic hypogonadism (CHH). Methods: Young male patients with CHH and healthy controls were recruited from the outpatient setting. Blood pressures, height, weight, waist circumference (WC), and blood tests including triglyceride (TG) level, insulin, homeostatic model assessment-insulin resistance (HOMA-IR), PLR, and NLR were calculated between CHH patients and controls and following TRT. Results: Sixty-six patients with CHH (mean age: 21.5±2.0 years) and 67 healthy controls (mean age: 21.9±1.3 years) were included in the study. CHH patients had higher platelet count (262.9±50.7 vs 232.1±49.2, p=0.001), MPV level (8.63±0.87 vs 8.16±0.92, p=0.004), PLR (114.01±25.68 vs 100.59±25.49, p=0.003), WC (86.8±9.1 vs 83.7±7.9, p=0.04), TG (96.0 vs 80.0, p=0.02), insulin (9.41 vs 6.92, p<0.001), and HOMA-IR (1.95 vs 1.47, p<0.001) than healthy controls. NLR was similar in both groups. After TRT, CHH patients showed significant elevations in body mass index, WC, total testosterone, and HOMA-IR and reduction in high density lipoprotein cholesterol level; however, platelet count, MPV, PLR, and NLR indices remained unchanged. Total testosterone level was also correlated with platelet count, MPV, and PLR. Conclusions: This study showed higher platelet count and surrogate markers of CV risk such as MPV and PLR in patients with CHH. However, short time TRT did not show any effect on these indices.
Yazarlar (7)
1
Ibrahim Demirci
ORCID: 0000-0002-6808-8550
2
Cem Haymana
3
Orhan Demir
4
Onur Akın
5
Coskun Meric
ORCID: 0000-0002-0766-0517
6
Aydogan Aydogdu
ORCID: 0000-0002-7983-1119
7
Alper Sonmez
Anahtar Kelimeler
cardiometabolic risk
Hypogonadism
NLR
PLR
testosterone
Kurumlar
Live Hospital
Ankara Turkey
Osmaniye State Hospital
Osmaniye Turkey
University of Health Sciences
Istanbul Turkey
Metrikler
2
Atıf
7
Yazar
5
Anahtar Kelime