Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Chemical Composition, Biological Activities and In Silico Analysis of Essential Oils of Three Endemic Prangos Species from Turkey
Molecules · Mart 2022
YÖKSİS Kayıtları
Chemical Composition, Biological Activities and In Silico Analysis of Essential Oils of Three Endemic Prangos Species from Turkey
MOLECULES · 2022 SCI-Expanded
PROFESÖR EVREN YILDIZTUGAY →
Makale Bilgileri
DergiMolecules
Yayın TarihiMart 2022
Cilt / Sayfa27
Scopus ID2-s2.0-85126008053
Erişim🔓 Açık Erişim
Özet
In this study, the essential oils (EOs) obtained from three endemic Prangos species from Turkey (P. heyniae, P. meliocarpoides var. meliocarpoides, and P. uechtritzii) were studied for their chemical composition and biological activities. β-Bisabolenal (12.2%) and caryophyllene oxide (7.9%) were the principal components of P. heyniae EO, while P. meliocarpoides EO contained sabinene (16.7%) and p-cymene (13.2%), and P. uechtritzii EO contained p-cymene (24.6%) and caryophyllene oxide (19.6%), as the most abundant components. With regard to their antioxidant activity, all the EOs were found to possess free radical scavenging potential demonstrated in both DPPH and ABTS assays (0.43–1.74 mg TE/g and 24.18–92.99 mg TE/g, respectively). Additionally, while no inhibitory activity was displayed by P. meliocarpoides and P. uechtritzii EOs against both cholinesterases (acetyl-and butyryl-cholinesterases). Moreover, all the EOs were found to act as inhibitors of tyrosinase (46.34–69.56 mg KAE/g). Molecular docking revealed elemol and α-bisabolol to have the most effective binding affinity with tyrosinase and amylase. Altogether, this study unveiled some interesting biological activities of these EOs, especially as natural antioxidants and tyrosinase inhibitors and hence offers stimulating prospects of them in the development of anti-hyperpigmentation topical formulations.
Yazarlar (9)
1
Gokhan Zengin
ORCID: 0000-0001-6548-7823
2
Mohamad Fawzi Mahomoodally
3
Evren Yildiztugay
ORCID: 0000-0002-4675-2027
4
Sharmeen Jugreet
5
Shafi Ullah Khan
6
Stefano Dall'Acqua
7
Adriano Mollica
8
Abdelhakim Bouyahya
ORCID: 0000-0001-9317-1631
9
Domenico Montesano
ORCID: 0000-0002-8857-2091
Anahtar Kelimeler
Antioxidant
Chemical composition
Enzyme inhibition
Essential oil
Molecular docking
Prangos
Kurumlar
Abasyn University
Peshawar Pakistan
Faculté des Sciences Rabat
Rabat Morocco
Selçuk Üniversitesi
Selçuklu Turkey
Università degli Studi di Napoli Federico II
Naples Italy
Università degli Studi di Padova
Padua Italy
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Mauritius
Reduit Mauritius
Metrikler
16
Atıf
9
Yazar
6
Anahtar Kelime