Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Gastroprotective and Antioxidant Effects of Ferula Plant Extract Against Indomethacin Induced Gastric Ulcer in Rats
Food Science and Nutrition · Ağustos 2025
YÖKSİS Kayıtları
Gastroprotective and Antioxidant Effects of Ferula Plant Extract Against Indomethacin Induced Gastric Ulcer in Rats
Food Science and Nutrition · 2025 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ MUHAMMED YAYLA →
Makale Bilgileri
DergiFood Science and Nutrition
Yayın TarihiAğustos 2025
Cilt / Sayfa13
Scopus ID2-s2.0-105012189836
Erişim🔓 Açık Erişim
Özet
Indomethacin is a non-steroidal anti-inflammatory drug and may cause oxidative damage in the stomach tissue. Scientific studies are carried out to discover alternative bioactive phytocompounds and to reveal herbal products with pharmacological effects. In our study, we investigated whether the Ferula, which is antimicrobial and anti-inflammatory, used for treatment of erectile dysfunction in men, menopausal disorders, diabetes, and prevention of osteoporosis, is effective in the treatment of gastric ulcer. 36 Sprague–Dawley adolescent male rats were divided into six groups: indomethacin, indomethacin + Famotidine, indomethacin + Ferula 400 mg, indomethacin + Ferula 800 mg, Ferula 800 mg, and healthy. It was determined that ulcerative areas were decreased in the high-dose group of Ferula extract. SOD, GSH, and CAT levels increased with Ferula extract in 800 mg doses, and MDA levels decreased with Ferula extract in 800 mg doses compared to the indomethacin group. TNF-α and p53 gene expression levels were decreased in Ferula extract in low doses (600 mg) compared to the indomethacin group. We determined that Ferula was effective in gastric ulcers. Ferula orientalis plant extract may be an alternative way to prevent drug-induced gastric ulcer. This anti-ulcer effect will be used as a food supplement in the future with further studies.
Yazarlar (10)
1
Serdar Yigit
ORCID: 0000-0001-5631-2335
2
Fatma Necmiye Kaci
3
Arzu Gezer
ORCID: 0000-0002-1658-2098
4
Muhammed Yayla
ORCID: 0000-0002-0659-3084
5
Lale Duysak
ORCID: 0000-0001-7872-3880
6
Pinar Aksu Kilicle
ORCID: 0000-0002-3567-5775
7
Erdem Toktay
ORCID: 0000-0002-0715-2707
8
Nilnur Eyerci
ORCID: 0000-0002-6293-3338
9
Gül Esma Akdogan Karadag
ORCID: 0000-0001-7959-2130
10
Seyit Ali Bingol
ORCID: 0000-0001-6422-9582
Anahtar Kelimeler
Ferula
indomethacin
p53
TNF-α
ulcer
Kurumlar
Atatürk Üniversitesi
Erzurum Turkey
Erzurum Teknik Üniversitesi
Erzurum Turkey
Kafkas Üniversitesi
Kars Turkey
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
1
Atıf
10
Yazar
5
Anahtar Kelime