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Angiogenesis biomarkers in prostate cancer: Unlocking new avenues for prognosis and diagnosis

Current Problems in Cancer · Aralık 2025

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YÖKSİS Kayıtları
Angiogenesis biomarkers in prostate cancer: Unlocking new avenues for prognosis and diagnosis
CURRENT PROBLEMS IN CANCER · 2025 SCI-Expanded
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Makale Bilgileri

DergiCurrent Problems in Cancer
Yayın TarihiAralık 2025
Cilt / Sayfa59
DOI10.1016/j.currproblcancer.2025.101253
Scopus ID2-s2.0-105017163246
Erişim🔓 Açık Erişim
Özet Objective: To evaluate the levels of angiogenesis-related biomarkers, including Thrombospondin-1 (TSP1), Endostatin, Osteopontin, and Tumstatin, in prostate cancer patients and their relationship with tumor spread and clinical parameters. Methods: This prospective study included 92 participants divided into three groups: 33 prostate cancer patients, 29 patients with benign prostatic hyperplasia (BPH), and 30 healthy controls. Biomarker levels were analyzed and compared among the groups. Results: Osteopontin levels were significantly higher in the prostate cancer group (108.5 ng/mL) compared to the BPH (66.02 ng/mL) and control groups (56.5 ng/mL). TSP1 levels were lower in prostate cancer group (16.3 ng/mL) than in the BPH (25.3 ng/mL) and control groups (21.5 ng/mL). Similarly, Endostatin levels were reduced in the prostate cancer group (146.3 ng/mL) compared to the BPH (163.3 ng/mL) and control groups (166.2 ng/mL). No significant differences in Tumstatin levels were observed among the groups. Conclusions: Elevated Osteopontin levels correlate with higher Gleason scores and metastatic potential, while lower TSP1 and Endostatin levels are associated with advanced tumor progression. These biomarkers may serve as indicators of prognosis in prostate cancer, though larger studies are required for validation.

Yazarlar (7)

1
Busra Ecer
2
Abdullah Sivrikaya
3
Gökhan Ecer
ORCID: 0000-0002-2805-8664
4
Serdar Goktas
ORCID: 0000-0001-6538-7187
5
Mehmet Yıldız
6
Mehmet Balasar
7
Ali Ünlü
ORCID: 0000-0002-9991-3939

Anahtar Kelimeler

Angiogenesis inhibitors Endostatin Osteopontin Prostate cancer biomarkers Thrombospondin-1 Tumstatin

Kurumlar

Aksaray Training and Research Hospital
Aksaray Turkey
Beyhekim Training and Research Hospital
Konya Turkey
Karapinar State Hospital
Konya Turkey
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey

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