Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Assessment of Serum suPAR Levels in Patients with Group 1 and Group 4 Pulmonary Hypertension
Journal of Clinical Medicine · Temmuz 2025
YÖKSİS Kayıtları
Assessment of Serum suPAR Levels in Patients with Group 1 and Group 4 Pulmonary Hypertension
Journal of Clinical Medicine · 2025 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ YASİN ÖZEN →
Assessment of Serum suPAR Levels in Patients with Group 1 and Group 4 Pulmonary Hypertension
Journal of Clinical Medicine · 2025 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ HÜSEYİN TEZCAN →
Makale Bilgileri
DergiJournal of Clinical Medicine
Yayın TarihiTemmuz 2025
Cilt / Sayfa14
Scopus ID2-s2.0-105019665274
Erişim🔓 Açık Erişim
Özet
Background/Objectives: Pulmonary hypertension (PH) is a progressive disorder with high morbidity and mortality, partly driven by chronic inflammation. Soluble urokinase plasminogen activator receptor (suPAR) reflects immune activation. We evaluated whether suPAR is altered in Group 1 and Group 4 PH and its association with clinical, echocardiographic, and laboratory parameters. Methods: We enrolled 44 PH patients (36 in Group 1, 8 in Group 4) and 45 healthy controls. All underwent clinical and echocardiographic assessments; right heart catheterization was performed in the PH patients. Serum suPAR was measured by ELISA. N-terminal pro B-type natriuretic peptide (NT-proBNP) and C-reactive protein (CRP) were also assessed. Results: The suPAR plasma levels in the PH group were between 23.91 and 960.8 pg/mL (median: 73.14 p25: 62.77, p75: 167.13). suPAR was significantly higher in PH versus controls (73.14 [62.77–167.13] vs. 65.52 [53.06–80.91] pg/mL; p = 0.012). In logistic regression, systolic blood pressure, erythrocyte sedimentation rate, NT-proBNP, and suPAR independently predicted PH. suPAR correlated negatively with six-minute walk distance (r = −0.310) and tricuspid annular plane systolic excursion (r = −0.295) but positively with systolic pulmonary artery pressure (r = 0.241). On multivariate analysis, six-minute walk distance was the only independent correlate of suPAR (p = 0.004). suPAR levels did not differ between Group 1 and Group 4 PH. Conclusions: suPAR is elevated in Group 1 and Group 4 PH and correlates with functional and echocardiographic indices of disease severity. Larger prospective studies are needed to determine suPAR’s role in diagnosis, risk stratification, and therapeutic decision-making.
Yazarlar (14)
1
Abdullah Tunçez
2
Muhammed Ulvi Yalçın
3
Hüseyin Tezcan
4
Bulent Behlul Altunkeser
5
Bahadır Öztürk
6
Canan Aydoğan
7
Aslıhan Merve Toprak
8
Onur Can Polat
9
Nazif Aygül
10
Kenan Demir
11
Kadri Murat Gurses
12
Yasin Özen
13
Fikret Akyürek
14
Hatice Betül Tunçez
Anahtar Kelimeler
biomarkers
diagnosis
pulmonary hypertension
suPAR
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey