Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q3
The impact of the L-dopa test on cortisol response and its comparison with the insulin tolerance test (comparative clinical study)
Medicine United States · Eylül 2025
YÖKSİS Kayıtları
The impact of the L-dopa test on cortisol response and its comparison with the insulin tolerance test (comparative clinical study)
Medicine (Baltimore) · 2025 SCI-Expanded
Dr. Öğr. Üyesi FATMA ÖZGÜÇ ÇÖMLEK →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Behçet Disease With Vascular Involvement effects of different therapeutic regimens on the incidence of new relapses
2015 ISSN: 0025-7974 SSCI
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Treatment of Clubfoot With Ponseti Method Using Semirigid Synthetic Softcast
2015 ISSN: 0025-7974 SSCI
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Does Previous Hip Surgery Effect the Outcome of Tönnis Triple Periacetabular Osteotomy Mid Term Results
2016 ISSN: 0025-7974 SSCI
Prof. Dr. BAHATTİN KEREM AYDIN →
Is serum high-mobility group box 1 (HMGB-1)level correlated with liver fibrosis in chronichepatitis B?
2017 ISSN: 0025-7974 SCI
Prof. Dr. ŞUA SÜMER →
Is serum high-mobility group box 1 (HMGB-1) level correlated with liver fibrosis in chronic hepatitis B?
2017 ISSN: 0025-7974 SCI
Prof. Dr. ONUR URAL →
Which of the fluorine-18 fluorodeoxyglucose positron emission tomography/computerized tomography parameters are better associated with prognostic factors in breast cancer?
2019 ISSN: 0025-7974 SCI-Expanded Q3
Doç. Dr. HASAN ÖNNER →
Association between RDW and stent thrombosis in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention
2017 ISSN: 0025-7974 SCI-Expanded
Prof. Dr. ABDULLAH TUNÇEZ →
How understandable are the patient education materials about flat foot on the Internet for parents?
2023 ISSN: 0025-7974 SCI-Expanded Q2
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How understandable are the patient education materials about flat foot on the Internet for parents?
2023 ISSN: 0025-7974 SCI-Expanded Q3
Doç. Dr. SELİM SAFALI →
The effects of pharmacomechanical thrombectomy on novel complete blood count parameters in deep vein thrombosis: A retrospective study
2023 ISSN: 0025-7974 SCI-Expanded Q3
Doç. Dr. ÖMER FARUK ÇİÇEK →
Evaluation of nipple vascularity using superb microvascular imaging in patients with reduction mammoplasty
2023 ISSN: 0025-7974 SCI-Expanded Q3
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How understandable are the patient education materials about flat foot on the Internet for parents?
2023 ISSN: 0025-7974 SCI-Expanded Q3
Prof. Dr. BAHATTİN KEREM AYDIN →
The validity and reliability of the Turkish version of the quality of recovery-15 (QoR-15) questionnaire
2024 ISSN: 0025-7974 SCI-Expanded Q2
Prof. Dr. İBRAHİM ÖZKAN ÖNAL →
The assessment of complementary and alternative medicine use in acne vulgaris patients in Turkey: A cross-sectional study
2024 ISSN: 0025-7974 SCI-Expanded Q2
Doç. Dr. BAHAR ÜRÜN ÜNAL →
The assessment of complementary and alternative medicine use in acne vulgaris patients in Turkey: A cross-sectional study
2024 ISSN: 0025-7974 SCI-Expanded Q2
Prof. Dr. KAMİLE MARAKOĞLU →
The validity and reliability of the Turkish version of the quality of recovery-15 (QoR-15) questionnaire
2024 ISSN: 0025-7974 SCI-Expanded Q2
Prof. Dr. MEHMET SARGIN →
Change in standardized uptake values in delayed 18F-FDG positron emission tomography images in hepatocellular carcinoma
2018 ISSN: 0025-7974 SCI Q2
Dr. Öğr. Üyesi KEVSER ÖKSÜZOĞLU →
The validity and reliability of the Turkish version of the quality of recovery-15 (QoR-15) questionnaire
2024 ISSN: 0025-7974 SCI-Expanded Q2
Prof. Dr. FARUK ÇİÇEKCİ →
Makale Bilgileri
Dergi
Medicine United States
ISSN00257974
Yayın TarihiEylül 2025
Cilt / Sayfa104 · e44442
Scopus ID2-s2.0-105015528961
Erişim🔓 Açık Erişim
Özet
Insulin tolerance tests (ITTs), glucagon tests, and low or standard-dose adrenocorticotropic hormone tests are used to evaluate the hypothalamic–pituitary–adrenal (HPA) axis. While ITT is considered the gold standard test for stimulating both the cortisol and growth hormone axis, its use in young children carries a risk of hypoglycemia, making it potentially unsafe. Recent studies indicate that L-dopa stimulates the release of adrenocorticotropic hormone and cortisol. This study aimed to evaluate the L-dopa test-evoked cortisol response in short children and compare it with the ITT. L-dopa and ITTs were used as growth hormone stimulation tests. Blood samples were collected from the subjects at 0, 30th, 60th, 90th, and 120th minutes to analyze growth hormone and cortisol levels. A serum cortisol level of >18 µg/dL in both tests was considered an adequate response for the HPA axis. All cases (100%) in the ITT showed a peak cortisol response more significant than 18 µg/dL. In comparison, an adequate cortisol response was achieved in 18 cases (90%) in the L-dopa test. When the time to reach peak cortisol levels was evaluated, in the L-dopa test, it was at the 120th minute in 70% of the cases (14 cases), and in the ITT, it was at the 60th minute in 65% of the cases (13 cases). The L-dopa stimulation test effectively controlled the HPA axis and stimulated cortisol levels similarly to ITT. In situations where the use of ITT is risky, the L-dopa test can be employed to monitor the HPA axis. Abbreviations: BMI = body mass index, GH = growth hormone, GHD = growth hormone deficiency, HPA = hypothalamic–pituitary–adrenal, IIH = insulin-induced hypoglycemia, ITTs = insulin tolerance tests.
Yazarlar (4)
1
Fatma Özgüç Çömlek
ORCID: 0000-0002-2752-3480
2
Hümeyra Yaşar Köstek
ORCID: 0000-0003-4268-3535
3
Emine Dilek
4
Filiz Tütüncüler Kökenli
ORCID: 0000-0003-3710-288X
Anahtar Kelimeler
cortisol
HPA axis
insulin tolerance test
L-dopa test
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Trakya University, Faculty of Medicine
Edirne Turkey
Scimago Dergi (ISSN Eşleşmesi)
Medicine (United States)
Q3
OA
SJR Skoru0,469
H-Index180
YayıncıLippincott Williams and Wilkins Ltd.
ÜlkeUnited States
Medicine (miscellaneous) (Q3)