Scopus
YÖKSİS Eşleşti
Efficacy of Wharton Jelly-Derived Mesenchymal Stem Cells Implanted on 3-Dimensional Hyaluronan-Based Scaffold in Tendon-Bone Interface Healing
Annals of Plastic Surgery · Ağustos 2025
YÖKSİS Kayıtları
Efficacy of wharton jelly–derived mesenchymal stem cells implanted on 3-dimensional hyaluronan-based scaffold in tendon-bone interface healing
Annals of Plastic Surgery · 2025 SCI-Expanded
DOÇENT GÖKÇE YILDIRAN →
Makale Bilgileri
DergiAnnals of Plastic Surgery
Yayın TarihiAğustos 2025
Cilt / Sayfa95 · 206-211
Scopus ID2-s2.0-105005859325
Özet
Introduction: The establishment of the enthesis unit remains a significant challenge due to the inability to reconstitute the native histological zones postrepair. In this study, the authors investigated the effect of 3-dimensional hyaluronan-based scaffold implanted with Wharton jelly-derived mesenchymal stem cells on enthesis healing in rat model. Methods: Three-dimensional hyaluronan-based scaffold was seeded with mesenchymal stem cells. Bilateral supraspinatus injury model created tendon-bone interface of 48 Sprague-Dawley rats reconstructed with one of the following: group 1: sham surgery; group 2: control group; group 3: surgery, scaffold and conditioned medium; group 4: surgery, scaffold and Wharton jelly-derived mesenchymal stem cells. The rats were killed on day 30, and supraspinatus-humerus tendon to bone unit was harvested en bloc for evaluations. Histopathological, immunohistochemical, mechanical, and micro-computed tomography evaluations were performed. Results: Group 4 was found to be superior to the others in terms of collagen organization and density, fibroblast growth factor, collagen II, and bone morphogenetic protein 2 immunoreactivity, as well as biomechanical tensile strength (P < 0,05). Additionally, groups 3 and 4 exhibited superior bone mineral density and trabecular thickness compared with the other groups. Conclusions: Wharton jelly-derived mesenchymal stem cells implanted into 3-dimensional hyaluronan-based scaffold have shown promising results in achieving a high strength enthesis unit resembling native histological zones.
Yazarlar (6)
1
Ahmet Rifat Doǧramaci
2
Gokce Yildiran
3
Gulsemin Cicek
ORCID: 0000-0003-2399-6755
4
Zeliha Esin Celik
5
Fatma Öz Bağcı
6
Zekeriya Tosun
Anahtar Kelimeler
enthesis
regeneration
scaffold
stem cell
tendon-to-bone healing
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Tip Fakültesi
Konya Turkey