Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Extractions of aerial parts of Hippomarathrum scabrum with conventional and green methodologies: Chemical profiling, antioxidant, enzyme inhibition, and anti-cancer effects
Journal of Separation Science · Ocak 2024
YÖKSİS Kayıtları
Extractions of aerial parts of Hippomarathrum scabrum with conventional and green methodologies: Chemical profiling, antioxidant, enzyme inhibition, and anti‐cancer effects
Journal of Separation Science · 2024 SCI-Expanded
Prof. Dr. EVREN YILDIZTUGAY →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Evaluation of new silica based humic acid stationary phase for the separation of tocopherols in cold pressed oils by normal phase high performance liquid chromatography
2015 ISSN: 16159306 SCI-Expanded
Prof. Dr. HAMİDE FİLİZ AYYILDIZ →
Preparation and chromatographic performance of calix 4 crown 5 macrocycle bonded silica stationary phase
2011 ISSN: 16159306 SCI-Expanded 6 atıf
Prof. Dr. SERKAN ERDEMİR →
New potential humic acid stationary phase toward drug components Development of a chemometric assisted RP HPLC method for the determination of paracetamol and caffeine in tablet formulations
2016 ISSN: 16159306 SCI-Expanded
Prof. Dr. HÜSEYİN KARA →
New potential humic acid stationary phase toward drug components Development of a chemometric assisted RP HPLC method for the determination of paracetamol and caffeine in tablet formulations
2016 ISSN: 16159306 SCI-Expanded
Prof. Dr. HAMİDE FİLİZ AYYILDIZ →
Simple high performance liquid chromatography method for formaldehyde determination in human tissue through derivatization with 2 4 dinitrophenylhydrazine
2016 ISSN: 16159306 SCI-Expanded
Dr. Öğr. Üyesi ALİ AŞCI →
Determination of metoprolol in human plasma and urine by high performance liquid chromatography with fluorescence detection
2010 ISSN: 16159306 SCI-Expanded
Dr. Öğr. Üyesi ALİ AŞCI →
Extractions of aerial parts of Hippomarathrum scabrum with conventional and green methodologies: Chemical profiling, antioxidant, enzyme inhibition, and anti‐cancer effects
2024 ISSN: 1615-9306 SCI-Expanded Q2
Prof. Dr. EVREN YILDIZTUGAY →
Separation and identification of different therapeutic pharmaceutical drugs on humic acid‐based HPLC column: Method optimization using central composite design
2023 ISSN: 1615-9306 SCI-Expanded Q2
Prof. Dr. HÜSEYİN KARA →
Separation and identification of different therapeutic pharmaceutical drugs on humic acid‐based HPLC column: Method optimization using central composite design
2023 ISSN: 1615-9306 SCI-Expanded Q2
Prof. Dr. HAMİDE FİLİZ AYYILDIZ →
Makale Bilgileri
ISSN16159306
Yayın TarihiOcak 2024
Cilt / Sayfa47
Scopus ID2-s2.0-85177546682
Özet
Hippomarathrum scabrum L. is an endemic medicinal plant in Turkey; however, there have been few studies investigating the phytochemistry and biological properties of these plants has not been investigated. The aim of this work is to determine the chemical composition of different extracts (extracts obtained by using supercritical carbon dioxide extraction, accelerated solvent extraction, homogenizer-assisted extraction, microwave-assisted extraction, and ultrasound-assisted extraction from Hippomarathrum scabrum L., and evaluate their biological properties. The analysis revealed that 5-O-caffeoylquinic acid, rutin, and isorhamnetin 3-O-rutinoside were the main bioactive compounds. The extract obtained by accelerated extraction contains the highest concentration of 5-O-Caffeoylquinic acid (7616.74 ± 63.09 mg/kg dry extract) followed by the extract obtained by homogenizer-assisted extraction (6682.53 ± 13.04 mg/kg dry extract). In antioxidant tests, all extracts expressed significant antioxidant activity. Also, cytotoxic and anticancer effects of these plant extracts were detected in the human prostate cancer cell line. Intrinsic apoptotic genes were up-regulated and anti-apoptotic genes were down-regulated in human prostate cancer cells after inhibition concentration dose treatment. The findings are promising, and suggest the use of these plant extracts could be used as natural sources with different biological activities, as well as anticancer agents.
Yazarlar (10)
1
Nilofar
2
Tugce Duran
ORCID: 0000-0002-7353-4527
3
Abdullahi Ibrahim Uba
4
Aleksandra Cvetanović Kljakić
5
Jelena Božunović
6
Uroš Gašić
7
Abdelhakim Bouyahya
ORCID: 0000-0001-9317-1631
8
Evren Yildiztugay
ORCID: 0000-0002-4675-2027
9
Claudio Ferrante
10
Gokhan Zengin
ORCID: 0000-0001-6548-7823
Anahtar Kelimeler
anti-cancer
antioxidant
extraction
Hippomarathrum scabrum
phenolics
phyto-pharmaceutics
Kurumlar
Faculté des Sciences Rabat
Rabat Morocco
İstanbul Arel Üniversitesi
Istanbul Turkey
Karatay Üniversitesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of Belgrade
Belgrade Serbia
University of G. d'Annunzio Chieti and Pescara
Chieti Italy
University of Novi Sad
Novi Sad Serbia
Scimago Dergi (ISSN Eşleşmesi)
Journal of Separation Science
Q2
SJR Skoru0,553
H-Index124
YayıncıJohn Wiley and Sons Inc
ÜlkeGermany
Analytical Chemistry (Q2)
Filtration and Separation (Q3)
Metrikler
14
Atıf
10
Yazar
6
Anahtar Kelime