Scopus
YÖKSİS Eşleşti
Pineal Gland and Melatonin are Associated with Serum Element Metabolism in Rats
Noropsikiyatri Arsivi · Eylül 2025
YÖKSİS Kayıtları
Pineal Gland and Melatonin are Associated with Serum Element Metabolism in Rats
Archives of neuropsychiatry · 2025 SCI-Expanded
PROFESÖR HALUK GÜMÜŞ →
Pineal Bez ve Melatonin Sıçanlarda Serum Element Metabolizması ile İlişkilidir
Nöropsikiyatri Arşivi · 2024 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ AYLİN ÜSTÜN →
Pineal Bez ve Melatonin Sıçanlarda Serum Element Metabolizması ile İlişkilidir
Nöropsikiyatri Arşivi · 2024 SCI-Expanded
PROFESÖR HALUK GÜMÜŞ →
Makale Bilgileri
DergiNoropsikiyatri Arsivi
Yayın TarihiEylül 2025
Cilt / Sayfa62 · 270-273
Scopus ID2-s2.0-105014974643
Özet
Introduction: The aim of this study is to investigate the relationship of melatonin supplementation with serum element metabolism in pinealectomized rats. Methods: The research was conducted on 32 adult male Spraque-Dawley rats. The study protocol was approved by the local animal ethics committee. Animals were divided into four equal groups. Control (Group 1), Melatonin (Group 2), Pinealectomy “Px” (Group 3), Pinealectomy+melatonin (Group 4). Animals in groups 2 and 4 were given intraperitoneal (ip) melatonin support (4 weeks/day; 3 mg/kg melatonin). Animals in groups 3 and 4 underwent pinealectomy under general anesthesia. At the end of the applications, serum element levels were determined by atomic emission (µg/dl) in the blood samples taken from the sacrificed animals. Results: While pinealectomy increased chromium and manganese levels in Group 3 (p<0.001), it caused significant suppression of magnesium, calcium and zinc levels (p<0.001). Melatonin supplementation in pinealectomized animals (Group 4) treated the impairments in the mentioned parameters. Conclusion: The results of the current study show that the melatonin hormone secreted from the pineal gland has a regulatory effect on serum element metabolism. This study is the first to examine the relationship between the pineal gland and element metabolism as a whole.
Yazarlar (6)
1
Aylı̇n Ustun
2
Zeynep Köykun
3
Haluk Gümüş
ORCID: 0000-0001-7689-7131
4
B. Yilmaz
5
Rasim Mogulkoc
6
Abdulkerim Kasim Baltaci
Anahtar Kelimeler
Elements metabolism
melatonin administration
pinealectomy
rat
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey
Vocational School of Health Services
Konya Turkey
Yeditepe University
Istanbul Turkey