Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
The Association Between Naples Prognostic Score and Coronary Collateral Circulation in Patients with Chronic Coronary Total Occlusion
Diagnostics · Ekim 2025
YÖKSİS Kayıtları
The Association Between Naples Prognostic Score and Coronary Collateral Circulation in Patients with Chronic Coronary Total Occlusion
Diagnostics · 2025 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ YASİN ÖZEN →
The Association Between Naples Prognostic Score and Coronary Collateral Circulation in Patients with Chronic Coronary Total Occlusion
Diagnostics · 2025 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ HÜSEYİN TEZCAN →
Makale Bilgileri
DergiDiagnostics
Yayın TarihiEkim 2025
Cilt / Sayfa15
Scopus ID2-s2.0-105019209488
Erişim🔓 Açık Erişim
Özet
Background: Coronary collateral circulation (CCC) plays a crucial protective role in patients with chronic total occlusion (CTO), mitigating ischemia and improving long-term outcomes. However, the degree of collateral vessel development varies substantially among individuals. Systemic inflammatory and nutritional status may influence this variability. The Naples Prognostic Score (NPS) is a composite index reflecting these parameters, yet its relationship with CCC remains incompletely defined. Methods: We retrospectively analyzed 324 patients with angiographically confirmed CTO at Selçuk University Faculty of Medicine between 2014 and 2025. Coronary collaterals were graded using the Rentrop classification, and patients were categorized as having poor (grades 0–1) or good (grades 2–3) collaterals. The NPS was calculated using serum albumin, cholesterol, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio. Baseline clinical and laboratory data were compared between groups. Univariate and multiple binary logistic regression analyses were performed to identify independent predictors of collateral development. Results: Of the 324 patients, 208 (64.2%) had poor and 116 (35.8%) had good collateral circulation. Patients with good collaterals had higher body mass index, HDL Cholesterol (HDL-C), and triglyceride levels, and significantly lower NPS values compared with those with poor collaterals (p < 0.05 for all). In multiple binary logistic regression analysis, HDL-C (OR 1.035; 95% CI 1.008–1.063; p = 0.011) and NPS (OR 0.226; 95% CI 0.130–0.393; p < 0.001) emerged as independent predictors of well-developed collaterals. Conclusions: Both NPS and HDL-C are independently associated with the degree of coronary collateral circulation in CTO patients. These findings highlight the interplay between systemic inflammation, nutritional status, lipid metabolism, and vascular adaptation. As simple and routinely available measures, NPS and HDL-C may serve as practical tools for risk stratification and identifying patients at risk of inadequate collateral formation. Prospective studies with functional assessments of collateral flow are warranted to confirm these associations and explore potential therapeutic interventions.
Yazarlar (12)
1
Abdullah Tunçez
2
Sevil Bütün
3
Kadri Murat Gurses
4
Hüseyin Tezcan
5
Aslıhan Merve Toprak Su
6
Burak Erdoğan
7
Mustafa Kırmızıgül
ORCID: 0009-0000-2704-3295
8
Muhammed Ulvi Yalçın
9
Yasin Özen
10
Kenan Demir
11
Nazif Aygül
12
Bulent Behlul Altunkeser
Anahtar Kelimeler
chronic total occlusion
coronary collateral circulation
high-density lipoprotein cholesterol
Naples prognostic score
rentrop classification
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey