Scopus
🔓 Açık Erişim YÖKSİS ISSN Eşleşti
SJR Q3
Association Between Sirtuin 1 (SIRT1) Gene Polymorphisms and Suicide Attempts in Schizophrenia: An Exploratory Study
Turk Psikiyatri Dergisi · Ocak 2025
YÖKSİS Kayıtları — ISSN Eşleşmesi
Comparison of the level of depression and anxiety in inactive hepatitis B carriers and chronic hepatitis B patients
2013 ISSN: 1300-2163 SSCI
Prof. Dr. ŞUA SÜMER →
Comparison of the Level of Depression and Anxiety in Inactive Hepatitis B Carriers and Chronic Hepatitis B Patient
2013 ISSN: 1300-2163 SSCI
Prof. Dr. NAZLIM AKTUĞ DEMİR →
Şizofreninin Ruhsal-Toplumsal Tedavisinde Sosyal Beceri Eğitimi -- Belirtilerle Başetme ve İlaç Tedavisi Yaklaşımının Türkiye’xxde Çok Merkezli Bir Uygulaması. / Social skills education in psycho-social treatment of schizophrenia.
2002 ISSN: 1300-2163 SSCI
Doç. Dr. AHMET HAKAN EKMEKCİ →
The Assessment of Obsessive-Compulsive Symptoms: Reliability and Validity of the Padua Inventory in Turkish Population
2015 ISSN: 1300-2163 SCI-Expanded
Prof. Dr. YAVUZ SELVİ →
A Case of Gitelman Syndrome Diagnosed with Anorexia Nervosa in a Psychiatry Clinic
2020 ISSN: 1300-2163 SSCI
Prof. Dr. MEMDUHA AYDIN →
Clinical Characteristics, Comorbid Medical Diagnoses, and Causes of Death of Individuals with Severe Mental Illness Who Died During Follow-up in Community Mental Health Centers: A Multicenter, Retrospective Study
2021 ISSN: 1300-2163 SCI-Expanded Q4
Prof. Dr. MEMDUHA AYDIN →
Psychiatric Association of Turkey, Scientific Section for Mood Disorders, Depression Treatment Guideline – I: Introduction, Terminology, Core Concepts, Assessment Methods
2025 ISSN: 1300-2163 SSCI Q3
Dr. Öğr. Üyesi RUKİYE TEKDEMİR →
Makale Bilgileri
Dergi
Turk Psikiyatri Dergisi
ISSN13002163
Yayın TarihiOcak 2025
Cilt / Sayfa36 · 553-563
Scopus ID2-s2.0-105018257271
Erişim🔓 Açık Erişim
Özet
Objective: Schizophrenia is a neuropsychiatric disorder with a high risk of suicide, arising from the interplay between genetic predisposition and environmental factors. The Sirtuin 1 (SIRT1) gene, an NAD<sup>+</sup>-dependent deacetylase, is involved in cellular stress response, apoptosis, and mitochondrial functions, as well as neuroprotection and circadian rhythm regulation. SIRT1 is thought to influence neurobiological mechanisms related to cognitive and affective regulation. This study aimed to investigate the association between specific SIRT1 gene polymorphisms and suicide attempts in patients with schizophrenia. Methods: This cross-sectional, observational genetic association study included only a case group comprising 100 patients diagnosed with schizophrenia. Targeted sequencing of the SIRT1 gene, encompassing all coding exons and their exon-intron junctions, was performed. Based on minor allele frequency and technical quality criteria, 10 single nucleotide polymorphisms (SNPs) were selected for further analysis. Linkage disequilibrium (LD) assessment, haplotype structure, and genetic modeling were conducted using the SHEsis software platform. Results: The rs10997870 GG genotype (p=0.017) and the rs7896005 AA genotype (p=0.033) were associated with suicide attempts, whereas the rs2236318 A allele (p=0.015) and the rs41299232 GG genotype (p=0.027) were found to be protective. The C-T-A-G haplotype (p=0.005) was associated with an increased risk, while the G-A-G-T haplotype (p=0.032) showed a protective effect. Conclusion: Certain polymorphisms and haplotypes within the SIRT1 gene may be associated with suicide risk among patients with schizophrenia. These findings point to the potential role of genetic profiling in identifying high-risk individuals. Further large-scale studies are warranted to increase the generalizability of the findings and to elucidate the underlying mechanisms in greater detail.
Yazarlar (3)
1
Ekrem Furkan Uçak
2
Memduha Aydin
3
Nadir Koçak
ORCID: 0000-0002-1104-1292
Anahtar Kelimeler
Haplotypes
schizophrenia
single nucleotide polymorphism
sirtuins
suicide attempt
Kurumlar
Afyonkarahisar Health Sciences University
Afyonkarahisar Turkey
Selçuk Tip Fakültesi
Konya Turkey
Scimago Dergi (ISSN Eşleşmesi)
Turk Psikiyatri Dergisi
Q3
SJR Skoru0,401
H-Index38
YayıncıTurkish Association of Nervous and Mental Health
ÜlkeTurkey
Medicine (miscellaneous) (Q3)
Psychiatry and Mental Health (Q3)
Metrikler
1
Atıf
3
Yazar
5
Anahtar Kelime