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From parasitic life to health-promoting applications - A versatile goldmine discovered in nature's secret treasure chest: Orobanche nana

Food Bioscience · Aralık 2024

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YÖKSİS Kayıtları
From parasitic life to health-promoting applications - a versatile goldmine discovered in natures secret treasure chest: Orobanche nana
Food Bioscience · 2024 SCI-Expanded
Prof. Dr. EVREN YILDIZTUGAY →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 20 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
Functional constituents of six wild edible Silene species: A focus on their phytochemical profiles and bioactive properties
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Functional constituents of six wild edible Silene species: A focus on their phytochemical profiles and bioactive properties
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Pigmented whole maize grains for functional value added and low glycemic index snack production
2021 ISSN: 2212-4292 SCI-Expanded Q1
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Pigmented Whole Maize Grains for Functional Value Added and Low Glycemic Index Snack Production
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Anticancer and biological properties of leaf and flower extracts of Echinacea purpurea (L.) Moench
2021 ISSN: 2212-4292 SCI-Expanded Q2
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Modulating of food glycemic response by lactic acid bacteria
2022 ISSN: 2212-4292 SCI-Expanded Q1
Prof. Dr. SULTAN ARSLAN TONTUL →
Integration of in vitro and in silico approaches to assess three Astragalus species from Turkey flora: A novel spotlight from lab bench to functional applications
2022 ISSN: 2212-4292 SCI-Expanded Q2
Prof. Dr. EVREN YILDIZTUGAY →
Evaluating the phyto-complexity and poly-pharmacology of spices: The case of Aframomum melegueta K. Schum (Zingiberaceae)
2022 ISSN: 2212-4292 SCI-Expanded Q1
Prof. Dr. GÖKHAN ZENGİN →
Effect of oat bran addition on the survival of selected probiotic strains in Turkish fermented sausage during cold storage
2023 ISSN: 2212-4292 SCI-Expanded Q2
Prof. Dr. CEMALETTİN SARIÇOBAN →
Revealing the proteolytic characteristics of lactobacillus, lacticaseibacillus, and lactiplantibacillus isolates by in vitro and in situ perspectives
2023 ISSN: 2212-4292 SCI-Expanded Q1
Doç. Dr. TALHA DEMİRCİ →
Storage stability, heat stability, controlled release and antifungal activity of liposomes as alternative fungal preservation agents
2023 ISSN: 2212-4292 SCI-Expanded Q1
Dr. Öğr. Üyesi MİNE ASLAN →
Unlocking the functional potential of Nitraria schoberi extracts using chemical fingerprinting, biological efficiencies, in silico and network pharmacological approaches
2024 ISSN: 2212-4292 SCI-Expanded Q1
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Harnessing the chemical composition and anti-oxidant, anti-enzymatic, and anti-cancer activities of two Corydalis species (C. erdelii and C. solida) by using in vitro and in silico analysis
2024 ISSN: 2212-4292 SCI-Expanded Q1
Prof. Dr. EVREN YILDIZTUGAY →
Effects of ultrasound-assisted marination on spent hen meats: Microstructure, textural and technological properties
2024 ISSN: 2212-4292 SCI Q1
Dr. Öğr. Üyesi HALİME ALP →
From parasitic life to health-promoting applications - a versatile goldmine discovered in natures secret treasure chest: Orobanche nana
2024 ISSN: 2212-4292 SCI-Expanded Q1
Prof. Dr. EVREN YILDIZTUGAY →
Effects of ultrasound-assisted marination on spent hen meats: Microstructure, textural and technological properties
2024 ISSN: 2212-4292 SCI-Expanded Q1
Doç. Dr. KÜBRA ÜNAL →
Exploring the chemical constituents and biological activities of leaf and twig extracts of two Amygdalus species from Turkeys flora: Cell-free, in vitro and molecular docking approaches
2025 ISSN: 2212-4292 SCI-Expanded Q1
Prof. Dr. EVREN YILDIZTUGAY →
Optimization of ultrasound-assisted extraction from Olea europaea leaves and analysis of their antioxidant and enzyme inhibition activities
2025 ISSN: 2212-4292 SCI Q1
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Chemical characterization and biological properties of oyster and shiitake mushrooms extracts and their liposomal formulations
2024 ISSN: 2212-4292 SCI-Expanded Q1
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Metabolomics-guided discrimination of constituents in five commercial apple (Malus × domestica Borkh.) cultivars: Assessment of their antioxidant, neuroprotective, and antidiabetic activities for potential use as functional food
2024 ISSN: 2212-4292 SCI-Expanded Q1
Prof. Dr. GÖKHAN ZENGİN →

Makale Bilgileri

Dergi Food Bioscience
ISSN22124292
Yayın TarihiAralık 2024
Cilt / Sayfa62
DOI10.1016/j.fbio.2024.105296
Scopus ID2-s2.0-85206801629
Özet Studies evaluating the phytoconstituents and therapeutic potential of species belonging to Orobanche (Family Orobanchaceae) are rather limited. The present study was designed to evaluate the chemical composition, antioxidant, enzyme inhibition and cytotoxic properties of the aerial parts of Orobanche nana Noë ex Rchb. Extracts were prepared by sequential maceration in dichloromethane, ethyl acetate and ethanol and finally an aqueous extraction by infusion were performed. NMR and LC-DAD-MS analysis allowed the identification of different phytoconstituents including the characteristic compounds of Orobanche like verbascoside, poliumoside, orobanone and orobanchoside. The ethanol extract displayed the highest total phenolic (115.63 mg GAE/g) and flavonoids (16.53 mg RE/g) contents, antiradical (DPPH = 623.70 mg TE/g; ATBS = 843.50 mg TE/g) and ions reducing (Cu++ = 725.39; Fe+++ = 617.70) properties while the aqueous extract exerted the best chelating power (19.54 mg EDTAE/g). It was determined that EtOH and Water extracts applied to HepG2 cells decreased the levels of anti-apoptotic proteins p-NFκB, BCL-2 and BCL-XL, while increasing the levels of apoptotic proteins BAX and p-53, thus inhibiting cell survival. In addition, Orobanche nana played an active role in the rearrangement of overexpress MMPs that cause disruption of ECM homeostasis. We employed Network Pharmacology to investigate the mechanisms through which Orobanche nana's compounds impact Kidney and Liver diseases. These findings suggested that O. nana could be a promising source of bioactive molecules with potential therapeutic applications.

Yazarlar (11)

1
Inci Kurt-Celep
2
Sakina Yagi
3
Stefano Dall'Acqua
4
Stefania Sut
5
Engin Celep
6
Savas Kaya
7
Avni Berisha
8
Sathish Kumar M. Ponnaiya
9
Kamalavarshini Balakrishnan
10
Evren Yildiztugay
ORCID: 0000-0002-4675-2027
11
Gokhan Zengin
ORCID: 0000-0001-6548-7823

Anahtar Kelimeler

antioxidant Cytotoxicity Enzyme inhibition Orobanche nana Phytoconstituents

Kurumlar

Acıbadem Mehmet Ali Aydınlar Üniversitesi
Istanbul Turkey
Cumhuriyet Üniversitesi
Sivas Turkey
Khartoum University
Khartoum Sudan
Okan Üniversitesi
Tuzla Turkey
Ponnaiya's Code and Genome Pvt Ltd
Madurai India
Selçuk Üniversitesi
Selçuklu Turkey
Università degli Studi di Padova
Padua Italy
Université de Lorraine
Nancy France
Universiteti i Prishtinës
Pristina Serbia
Scimago Dergi (ISSN Eşleşmesi)
Food Bioscience
Q1
SJR Skoru1,119
H-Index94
YayıncıElsevier Ltd
ÜlkeUnited Kingdom
Biochemistry (Q1)
Food Science (Q1)
Dergi sayfasına git

Metrikler

5
Atıf
11
Yazar
5
Anahtar Kelime

Sistemimizdeki Yazarlar

EY
EVREN YILDIZTUGAY
Prof. Dr.

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