Scopus
YÖKSİS DOI Eşleşti
SJR Q3
Preparation and Evaluation of Nicotine and Quercetin Loaded Polyvinyl Alcohol Nanofiber Wound Dressings
Journal of Pharmaceutical Innovation · Aralık 2025
YÖKSİS Kayıtları
Preparation and Evaluation of Nicotine and Quercetin Loaded Polyvinyl Alcohol Nanofiber Wound Dressings
JOURNAL OF PHARMACEUTICAL INNOVATION · 2025 SCI-Expanded
Dr. Öğr. Üyesi DİLARA ÖRGÜL →
Preparation and Evaluation of Nicotine and Quercetin Loaded Polyvinyl Alcohol Nanofiber Wound Dressings
Journal of Pharmaceutical Innovation · 2025 SCI-Expanded
Dr. Öğr. Üyesi YAKUP GÜLTEKİN →
Preparation and Evaluation of Nicotine and Quercetin Loaded Polyvinyl Alcohol Nanofiber Wound Dressings
JOURNAL OF PHARMACEUTICAL INNOVATION · 2025 SCI
Dr. Öğr. Üyesi DİLARA ÖRGÜL →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Evaluation of Dual Effect of Sodium Borohydride (NaBH4) as a Reducing and Crosslinking Agent for Development of Novel Silver Nanoparticles (AgNPs) Loaded Chitosan-Poly (Vinyl Alcohol) (CS-PVA) Hydrogels for Wound Healing Activity
2026 ISSN: 1872-5120 SCI-Expanded Q2
Dr. Öğr. Üyesi YAKUP GÜLTEKİN →
Development of Film Formulations of Acyclovir as Safe and Effective Antiviral Agent: Optimization, In Vitro Characterization and Antialphaherpesviral Efficacy
2026 ISSN: 1872-5120 SCI-Expanded Q2
Dr. Öğr. Üyesi DİLARA ÖRGÜL →
Preparation and Evaluation of Nicotine and Quercetin Loaded Polyvinyl Alcohol Nanofiber Wound Dressings
2025 ISSN: 1872-5120 SCI-Expanded Q2
Dr. Öğr. Üyesi YAKUP GÜLTEKİN →
Preparation and Evaluation of Nicotine and Quercetin Loaded Polyvinyl Alcohol Nanofiber Wound Dressings
2025 ISSN: 1872-5120 SCI-Expanded Q2
Dr. Öğr. Üyesi DİLARA ÖRGÜL →
Makale Bilgileri
ISSN18725120
Yayın TarihiAralık 2025
Cilt / Sayfa20
Scopus ID2-s2.0-105019338879
Özet
The skin, which is a protective barrier for the human body, can be injured from time to time as a result of disease or trauma. Electrospun nanofiber wound dressings made from biopolymers for skin regeneration and wound healing have been widely investigated in recent years. This study successfully prepared PVA-based nanofiber wound dressings loaded with nicotine and quercetin by the electrospinning method to accelerate wound healing. The nanofibers were characterized morphologically, physically, and chemically, and then their cytotoxicity levels and effects on wound healing were evaluated in vitro. First, three different concentrations of PVA solutions were prepared, and one nanofiber wound dressing was produced with each of them. Next, characterization studies of the nanofiber wound dressings were performed, and the optimal formulation was selected. Morphological examinations by SEM analysis revealed that homogeneous and uniform nanofibers with an average diameter of 122.11 ± 36.22 nm and no bead formation were successfully produced. The structural properties of the nanofiber wound dressings were evaluated by DSC and FTIR analyses, which revealed that there was no significant physico-chemical interaction between the polymer and the loaded drugs. In terms of drug loading efficiency, the loading efficiency of nicotine was found to be higher compared to quercetin (quercetin: 21.86 ± 2.1%; nicotine: 99.43 ± 6.1%), and it was also determined that the nanofiber structure produced increased the solubility of quercetin by approximately two times. The results of MTT assay on L929 cells revealed that the prepared nanofiber wound dressings did not show cytotoxicity, on the contrary, they supported biocompatibility by increasing cell viability. The wound-healing process was evaluated using an in vitro scratch test. The F2 nanofiber wound dressing produced approximately a 3-fold increase in wound closure compared to the control. Studies have shown that nicotine and quercetin-loaded PVA nanofiber dressings have the potential to accelerate wound healing.
Yazarlar (4)
1
Yakup Gultekin
2
Dilara Orgul
3
Zeynep Çetinkaya
ORCID: 0000-0002-4591-2332
4
İmran Vural
Anahtar Kelimeler
Nanofiber
Nicotine
Polyvinyl alcohol
Quercetin
Wound healing
Kurumlar
Hacettepe Üniversitesi
Ankara Turkey
Konya Technical University
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of Colorado Boulder
Boulder United States
Scimago Dergi (ISSN Eşleşmesi)
Journal of Pharmaceutical Innovation
Q3
SJR Skoru0,367
H-Index43
YayıncıSpringer
ÜlkeUnited States
Drug Discovery (Q3)
Pharmaceutical Science (Q3)