Scopus
🔓 Açık Erişim
Drug-Induced Periocular and Ocular Surface Disorders: An EAACI Position Paper
Allergy European Journal of Allergy and Clinical Immunology · Kasım 2025
Makale Bilgileri
DergiAllergy European Journal of Allergy and Clinical Immunology
Yayın TarihiKasım 2025
Cilt / Sayfa80 · 2953-2972
Scopus ID2-s2.0-105018207628
Erişim🔓 Açık Erişim
Özet
Various systemic and topical medications can induce ocular and periocular cutaneous adverse effects (AEs), ranging from mild to severe. These AEs may lead to ocular surface (OS) damage and, in some cases, life-threatening complications. Drug-induced ocular adverse reactions are generally classified into two primary categories: toxic reactions and/or allergic hypersensitivity reactions, which can be IgE or non-IgE-mediated. Systemic antibiotics, antivirals, and anticonvulsants can trigger adverse reactions that may involve the OS. Drugs like antihistamines, beta-blockers, antipsychotics, antidepressants, and isotretinoin are linked to dry eye disease. Topical treatments—including antibiotics, antiglaucoma medications, preservatives, contact lens solutions, and cosmetics—may elicit allergic or toxic ocular diseases. Recent evidence implicates ocular surface AEs in patients undergoing biological treatments for oncological diseases and atopic dermatitis. Epidermal growth factor receptor inhibitors, used in the treatment of several cancers, have been associated with conjunctivitis, meibomitis, dry eye, periocular skin changes, and trichomegaly. Similarly, dupilumab, the first biologic approved for treating moderate-to-severe atopic dermatitis, has also been linked to OS disease with blepharoconjunctivitis. This position paper provides a comprehensive overview of the clinical presentations, diagnostic approaches, and treatment strategies for drug-induced ocular AEs, integrating the latest literature and clinical guidelines.
Yazarlar (17)
1
Andrea Leonardi
ORCID: 0000-0002-7246-8580
2
Banu Bozkurt
ORCID: 0000-0002-9847-3521
3
Diana Silva
4
Charlotte G. Mortz
ORCID: 0000-0001-8710-0829
5
Christophe Baudouin
6
Marina Atanaskovic-Markovic
ORCID: 0000-0003-1354-6072
7
Vibha Sharma
8
Serge Doan
9
Shweta Agarwal
10
Daniel Perez Formigo
11
Maria Joao Vasconcelos
12
Francoise Brignole Baudouin
13
Gonzalo Chorzepa
14
Jean L. Fauquert
15
Virginia Calder
16
Pascal Demoly
ORCID: 0000-0001-7827-7964
17
Luis Delgado
Anahtar Kelimeler
biological treatments
drug related blepharoconjunctivitis
ocular allergy
ocular drug hypersensitivity reactions
severe cutaneous adverse reactions
Kurumlar
Centre Hospitalier Universitaire de Clermont-Ferrand
Clermont-Ferrand France
Centre Hospitalier Universitaire de Montpellier
Montpellier France
CUF Porto Instituto & Hospital
Porto Portugal
Faculdade de Medicina da Universidade do Porto (FMUP)
Porto Portugal
Fondation Adolphe de Rothschild
Paris France
Hospital Lusíadas Porto
Porto Portugal
Hospital Universitario de Torrejón
Madrid Spain
Immunoallergology Service
Porto Portugal
Inserm
Paris France
Medical Research Foundation, Chennai
Chennai India
Odense Universitetshospital
Odense Denmark
Royal Manchester Children's Hospital
Manchester United Kingdom
Sanatorio Parque
Rosario Argentina
Selçuk Tip Fakültesi
Konya Turkey
The University of Manchester
Manchester United Kingdom
UCL Institute of Ophthalmology
London United Kingdom
Universidade do Porto
Porto Portugal
Università degli Studi di Padova
Padua Italy
Université Paris Cité
Paris France
Université Paris-Saclay
Gif-sur-Yvette France
University Children's Hospital, Belgrade
Belgrade Serbia