Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q2
Correlation in the change of gut microbiota with clinical periodontal parameters in grade C periodontitis patients after non-surgical periodontal therapy
Journal of Medical Microbiology · Ocak 2025
YÖKSİS Kayıtları
Correlation in the change of gut microbiota with clinical periodontal parameters in grade C periodontitis patients after non-surgical periodontal therapy
Journal of Medical Microbiology · 2025 SCI-Expanded
Dr. Öğr. Üyesi EMİNE ELİF MUTAFCILAR VELİOĞLU →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Molecular epidemiology of vancomycin resistant Enterococcus faecium strains isolated from haematological malignancy patients in a research hospital in Turkey
2010 ISSN: 0022-2615 SCI-Expanded 4 atıf
Prof. Dr. UĞUR ARSLAN →
Correlation in the change of gut microbiota with clinical periodontal parameters in grade C periodontitis patients after non-surgical periodontal therapy
2025 ISSN: 0022-2615 SCI-Expanded Q3
Dr. Öğr. Üyesi EMİNE ELİF MUTAFCILAR VELİOĞLU →
Makale Bilgileri
ISSN00222615
Yayın TarihiOcak 2025
Cilt / Sayfa74
Scopus ID2-s2.0-105018291597
Erişim🔓 Açık Erişim
Özet
Introduction. Intestinal dysbiosis is associated with systemic health, and approaches targeting the microbiome can influence the host. Oral and intestinal microbiota are interrelated; therefore, we aimed to determine whether non-surgical periodontal treatment (NSPT) affects systemic health through its impact on the intestinal microbiota. Hypothesis/Gap Statement. Although the association between oral and gut microbiota has been suggested, there is limited evidence regarding how periodontal therapy may influence intestinal microbial composition. We hypothesized that NSPT in patients with periodontitis would lead to favourable changes in the gut microbiome, which may parallel improvements in clinical periodontal parameters. Aim. This study aimed to investigate the effect of NSPT on both oral and intestinal microbiota and to evaluate whether changes in gut microbial composition correlate with periodontal clinical outcomes. Methodology. Five systemically healthy individuals with grade C periodontitis and five systemically and periodontally healthy individuals were included. Saliva and stool samples were collected at baseline and 1 month after NSPT. DNA extractions were performed and subjected to 16S ribosomal RNA gene sequencing on the Illumina Novaseq at the V3–V4 hypervariable regions. Results. Grade C periodontitis patients displayed distinct oral and gut microbiomes compared to healthy individuals. NSPT resulted in a reduction in the diversity of both saliva and stool samples in healthy individuals (P>0.05). Salivary Fusobacteriota levels (P<0.05) and the gut Firmicutes/Bacteroides ratio decreased after NSPT. Moreover, changes in gut microbiota significantly correlated with improvements in periodontal probing depth and clinical attachment level in periodontitis patients. Conclusion. The improvement in clinical periodontal parameters after NSPT correlates with a positive shift in the gut microbiome towards health. Although the number of participants was limited, these findings support a strong relationship between periodontal and gut status. Further studies with larger cohorts and long-term follow-up are required to confirm these results.
Yazarlar (6)
1
E. Elif Mutafcilar Velioğlu
ORCID: 0000-0003-1882-553X
2
Ugur Arslan
3
Seyit Ali Kayis
4
Salih Maçin
ORCID: 0000-0002-1871-3629
5
Nobuhiko Kamada
ORCID: 0000-0002-1980-4178
6
Sema S. Hakkı
Anahtar Kelimeler
gut microbiota
metagenomics
oral microbiota
periodontal health
periodontitis
Kurumlar
Abant Izzet Baysal University, Faculty of Medicine
Bolu Turkey
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of Michigan Medical School
Ann Arbor United States
Scimago Dergi (ISSN Eşleşmesi)
Journal of Medical Microbiology
Q2
OA
SJR Skoru0,723
H-Index140
YayıncıMicrobiology Society
ÜlkeUnited Kingdom
Medicine (miscellaneous) (Q2)
Microbiology (Q2)
Microbiology (medical) (Q2)