Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q3
Effects of dexmedetomidine on cardiac electrical activity and ion currents: An experimental animal study
Turkish Journal of Biochemistry · Ağustos 2025
YÖKSİS Kayıtları
Effects of dexmedetomidine on cardiac electrical activity and ion currents: an experimental animal study
Turkish Journal of Biochemistry · 2025 SCI-Expanded
Prof. Dr. OĞUZHAN ARUN →
Effects of dexmedetomidine on cardiac electrical activity and ion currents: an experimental animal study
Turkish Journal of Biochemistry · 2025 SCI-Expanded
Dr. Öğr. Üyesi FUNDA ARUN →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Asymmetric dimethylarginine and arginine levels in patients with rheumatoid arthritis
2013 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. ALİ ÜNLÜ →
Asymmetric dimethylarginine and arginine levels in patients with rheumatoid arthritis
2013 ISSN: 0250-4685 SCI-Expanded 3 atıf
Prof. Dr. ALİ ÜNLÜ →
Asymmetric dimethylarginine levels in Behçet s Disease
2014 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. BAHADIR ÖZTÜRK →
Asymmetric dimethylarginine levels in Behçet s Disease
2014 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. HÜSAMETTİN VATANSEV →
Asymmetric dimethylarginine and arginine levels in patients with rheumatoid arthritis
2013 ISSN: 0250-4685 SCI-Expanded 3 atıf
Prof. Dr. HÜSAMETTİN VATANSEV →
Asymmetric dimethylarginine and arginine levels in patients with rheumatoid arthritis
2013 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. ABDULLAH SİVRİKAYA →
Is median value of Double Screening Test regional?
2015 ISSN: 0250-4685 SCI-Expanded Q4
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Calculation of measurement uncertainty of biochemical parameters
2015 ISSN: 02504685 SCI-Expanded
Prof. Dr. SEDAT ABUŞOĞLU →
The effects of grape seed extract against toxicity of benzene on liver and kidney tissues of albino mice biochemical evaluation
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Analysis of trace elements in epileptic patients
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Serum Paraoxonase Levels and Oxidative Stress in Patients with Scleroderma
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Analysis of Trace Elements in Epileptic Patients
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The Analytical Performance of The C Petide and Insuline Test
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Procalcitonin Levels in Inflammatory Disease
2015 ISSN: 0250-4685 SCI-Expanded
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Comparison of Routine Biochemical and Hormonal Values of Sleeve Gastrectomy Applied Patients
2015 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. HÜSAMETTİN VATANSEV →
Comparison Of MPV WBC and Neutrophil Lymphocyte Ratio of Sleeve Gastrectomy Applied Patients
2015 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. HÜSEYİN YILMAZ →
Influence of Pinealectomy on Hemogram Parameters of Rats Applied to Sepsis Model
2015 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. HÜSAMETTİN VATANSEV →
Meme Kanser Hücrelerinin Fluıdıgm Dynamıc Array Kullanılarak Kantitatif miRNA Ekspresyaon Analizi
2015 ISSN: 0250-4685 SCI-Expanded
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25 OH D3 ve 1 25 OH 2 D3 ün MCF 7 Meme Kanser Hücre Hattının Proliferasyonu Üzerine Kıyaslanması
2015 ISSN: 0250-4685 SCI-Expanded
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The effect of single dose administration of nandrolone decanoate on plasma irisin adropin leptin levelsTek doz nandrolon dekonat uygulamasının plazma irisin adropin leptin düzeylerine etkisi
2015 ISSN: 0250-4685 SCI-Expanded
Prof. Dr. SEYFULLAH HALİLOĞLU →
Makale Bilgileri
ISSN02504685
Yayın TarihiAğustos 2025
Cilt / Sayfa50 · 520-529
Scopus ID2-s2.0-105016492800
Erişim🔓 Açık Erişim
Özet
Objectives: Dexmedetomidine is a potent and highly selective alpha-2 adrenergic receptor agonist recognized for its sedative, hypnotic, analgesic, and sympatholytic properties. The diverse cardiac and hemodynamic effects of dexmedetomidine have been thoroughly documented. Consequently, we investigated its impact on electrophysiological parameters, including action potential and contraction in ventricular myocytes. Methods: Freshly isolated ventricular myocytes from adult Wistar rats were used for experiments. The contraction and relaxation responses, action potentials, L-type calcium currents, and potassium channel currents of the myocytes were recorded using a video-based contractility system and the whole-cell patch clamp technique. Results: While higher concentrations of dexmedetomidine progressively inhibit the contractile responses of cardiomyocytes, they did not significantly impact the action potential repolarization phase or potassium currents (including both transient outward and inward rectifiers). However, there was a decrease in L-type calcium currents, particularly at potential values ranging from 0 to 30mV. Furthermore, although dexmedetomidine shifted the V50 value toward more positive values in the deactivation-reactivation curve of the L-type calcium channel, no statistically significant difference was observed. Conclusions: Our study demonstrates that dexmedetomidine causes a dose-dependent reduction in contractility and decreases calcium currents. These findings indicate that dexmedetomidine may significantly influence the mechanical and electrical functions of cardiac cells. Additional research is needed to clarify the molecular mechanisms underlying these changes.
Yazarlar (7)
1
Funda Arun
ORCID: 0000-0001-7345-0318
2
Nihal Ozturk
ORCID: 0000-0002-8681-1415
3
Orhan Erkan
ORCID: 0000-0001-7226-2438
4
Semir Ozdemir
ORCID: 0000-0002-4807-7344
5
Oguzhan Arun
ORCID: 0000-0001-6101-1481
6
Sırma Basak Yanardag
ORCID: 0009-0001-5327-8706
7
Murat Ayaz
Anahtar Kelimeler
action potential
calcium current
cardiac electrical activity
dexmedetomidine
ion currents
potassium current
Kurumlar
Akdeniz University, Faculty of Medicine
Antalya Turkey
Independent Researcher
Konya Turkey
Kafkas Üniversitesi
Kars Turkey
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Turkish Journal of Biochemistry
Q3
OA
SJR Skoru0,232
H-Index26
YayıncıWalter de Gruyter GmbH
ÜlkeGermany
Biochemistry (medical) (Q3)
Biochemistry (Q4)
Clinical Biochemistry (Q4)
Molecular Biology (Q4)