Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Effects of dexmedetomidine on cardiac electrical activity and ion currents: An experimental animal study
Turkish Journal of Biochemistry · Ağustos 2025
YÖKSİS Kayıtları
Effects of dexmedetomidine on cardiac electrical activity and ion currents: an experimental animal study
Turkish Journal of Biochemistry · 2025 SCI-Expanded
PROFESÖR OĞUZHAN ARUN →
Effects of dexmedetomidine on cardiac electrical activity and ion currents: an experimental animal study
Turkish Journal of Biochemistry · 2025 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ FUNDA ARUN →
Makale Bilgileri
DergiTurkish Journal of Biochemistry
Yayın TarihiAğustos 2025
Cilt / Sayfa50 · 520-529
Scopus ID2-s2.0-105016492800
Erişim🔓 Açık Erişim
Özet
Objectives: Dexmedetomidine is a potent and highly selective alpha-2 adrenergic receptor agonist recognized for its sedative, hypnotic, analgesic, and sympatholytic properties. The diverse cardiac and hemodynamic effects of dexmedetomidine have been thoroughly documented. Consequently, we investigated its impact on electrophysiological parameters, including action potential and contraction in ventricular myocytes. Methods: Freshly isolated ventricular myocytes from adult Wistar rats were used for experiments. The contraction and relaxation responses, action potentials, L-type calcium currents, and potassium channel currents of the myocytes were recorded using a video-based contractility system and the whole-cell patch clamp technique. Results: While higher concentrations of dexmedetomidine progressively inhibit the contractile responses of cardiomyocytes, they did not significantly impact the action potential repolarization phase or potassium currents (including both transient outward and inward rectifiers). However, there was a decrease in L-type calcium currents, particularly at potential values ranging from 0 to 30mV. Furthermore, although dexmedetomidine shifted the V50 value toward more positive values in the deactivation-reactivation curve of the L-type calcium channel, no statistically significant difference was observed. Conclusions: Our study demonstrates that dexmedetomidine causes a dose-dependent reduction in contractility and decreases calcium currents. These findings indicate that dexmedetomidine may significantly influence the mechanical and electrical functions of cardiac cells. Additional research is needed to clarify the molecular mechanisms underlying these changes.
Yazarlar (7)
1
Funda Arun
ORCID: 0000-0001-7345-0318
2
Nihal Ozturk
ORCID: 0000-0002-8681-1415
3
Orhan Erkan
ORCID: 0000-0001-7226-2438
4
Semir Ozdemir
ORCID: 0000-0002-4807-7344
5
Oguzhan Arun
ORCID: 0000-0001-6101-1481
6
Sırma Basak Yanardag
ORCID: 0009-0001-5327-8706
7
Murat Ayaz
Anahtar Kelimeler
action potential
calcium current
cardiac electrical activity
dexmedetomidine
ion currents
potassium current
Kurumlar
Akdeniz University, Faculty of Medicine
Antalya Turkey
Independent Researcher
Konya Turkey
Kafkas Üniversitesi
Kars Turkey
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey