Scopus
YÖKSİS Eşleşti
Relationship of kynurenine pathway metabolites and indoleamine 2,3-dioxygenase with atherosclerosis: data obtained from pericardial fluid in coronary artery bypass surgery
Scandinavian Journal of Clinical and Laboratory Investigation · Ocak 2025
YÖKSİS Kayıtları
Relationship of kynurenine pathway metabolites and indoleamine 2,3-dioxygenase with atherosclerosis: data obtained from pericardial fluid in coronary artery bypass surgery
Scandinavian Journal of Clinical and Laboratory Investigation · 2025 SCI-Expanded
PROFESÖR SEDAT ABUŞOĞLU →
Relationship of kynurenine pathway metabolites and indoleamine 2,3-dioxygenase with atherosclerosis: data obtained from pericardial fluid in coronary artery bypass surgery
Scandinavian Journal of Clinical and Laboratory Investigation · 2025 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
Makale Bilgileri
DergiScandinavian Journal of Clinical and Laboratory Investigation
Yayın TarihiOcak 2025
Cilt / Sayfa85 · 509-517
Scopus ID2-s2.0-105017862933
Özet
Analyzing the local pericardial fluid (PF) surrounding the heart can provide insights into the function of myocardial and pericardial epithelial cells. Kynurenine (KYN) metabolites have been associated with endothelial dysfunction and the progression of atherosclerosis. This study investigated the relationship between KYN pathway metabolites in serum and PF and the severity of coronary atherosclerosis, as assessed by the Syntax Score (SS). The study involved 101 patients (mean age: 60 years). Of the participants, 17% were female. KYN and its metabolite levels were measured using API SCIEX 3200 LC-MS/MS methods. Statistical analysis was performed using IBM SPSS 25.0. The mean serum levels of tryptophan (TRP), 3-hydroxykynurenine (3-HK), and 3-hydroxyanthranilic acid were significantly higher (p < 0.01) when compared to the mean PF levels. In the SS-low group, PF IDO activity was significantly higher than serum IDO activity (p = 0.040). In the SS-high group, PF IDO activity was significantly higher than serum IDO activity (p = 0.002). The mean 3-HK measurements showed significant differences between the SS groups (p < 0.05). In this study, higher IDO enzyme activity in the PF compared to systemic circulation suggests the presence of inflammatory activity in the pericardial endothelial cells. This research aimed to uncover the role of amino acid metabolism, which is poorly understood in atherosclerosis. Specifically, 3-HK, a metabolite from the KYN pathway, may contribute to the development of atherosclerosis. These findings indicate that localized kynurenine pathway activation in the PF may contribute to coronary atherosclerosis, highlighting its potential as a biomarker or therapeutic target.
Yazarlar (7)
1
Hakan Çomaklı
ORCID: 0000-0002-7510-298X
2
Mohammad Ahmad Bik
ORCID: 0000-0003-1577-6525
3
Ali Ünlü
ORCID: 0000-0002-9991-3939
4
Sedat Abusoglu
ORCID: 0000-0002-2984-0527
5
Mehmet Murat Yiğitbaşı
ORCID: 0000-0002-6049-9910
6
Mert Demirsöz
7
Şeref Alp Küçüker
Anahtar Kelimeler
Atherosclerosis
coronary artery disease
kynurenine
pericardial fluid
tryptophan
Kurumlar
Ankara Bilkent City Hospital
Ankara Türkiye
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey