Scopus
YÖKSİS Eşleşti
Assessment of the protective effects of pomegranate peel extract and N-acetyl cysteine alone or in combination with Ornipural® against Cadmium-induced bone toxicity in rat
Eurasian Journal of Veterinary Sciences · Ocak 2024
YÖKSİS Kayıtları
Assessment of the protective effects of pomegranate peel extract and N-acetyl cysteine alone or in combination with Ornipural® against Cadmium-induced bone toxicity in rat
Eurasian Journal of Veterinary Sciences · 2024 TR DİZİN
DOÇENT DURMUŞ HATİPOĞLU →
Assessment of the protective effects of pomegranate peel extract and N-acetyl cysteine alone or in combination with Ornipural® against Cadmium-induced bone toxicity in rat
Eurasian Journal of Veterinary Sciences · 2024 Zoolological Record
PROFESÖR BURAK DİK →
Makale Bilgileri
DergiEurasian Journal of Veterinary Sciences
Yayın TarihiOcak 2024
Cilt / Sayfa40 · 24-33
Scopus ID2-s2.0-105011292735
Özet
Aim: The present study was conducted to determine the effects of pomegranate peel extract (PPE) and N-acetyl Cysteine (NAC) alone or in their treatment combinations with commercial preparation Ornipural® (ORN) on bone metabolism against experimentally cadmium (Cd)-induced toxicity in rats. Materials and Methods: Totally 36 animals were used in the study including 6 Wistar Albino rats in each group. The animals were assigned to control, Cd, Cd+PPE, Cd+NAC, Cd+PPE+ORN and Cd+NAC+ORN groups. The animals in the groups were euthanized after their blood samples were taken at the end of the 8th week. The bones were subjected to maceration for morphometric and histopathological examinations after euthanasia. Results: The statistically significant differences were determined between the treatment groups and Cd group in terms of histopathological changes (osteoporotic alterations and changes in red bone marrow) and biomarkers (Ca, P and Mg) (P<0.05). Conclusion: Although PPE, NAC and treatment combinations with ORN applied against experimentally induced cadmium toxicity were determined to have positive effects on bone metabolism, it has been thought that carrying out trials by increasing treatment duration and dose would be beneficial to determine definite efficacy of the applied treatment protocols.
Yazarlar (7)
1
Durmus Hatipoglu
ORCID: 0000-0003-3790-7821
2
Ismail Demircioǧlu
3
Kursat Filikci
4
Yasemin Korkmaz
ORCID: 0000-0002-1990-2691
5
Huseyin Gungor
ORCID: 0000-0002-2506-3855
6
Muhammed Demircioglu
7
Burak Dik
Anahtar Kelimeler
Bone toxicity
cadmium
N-acetyl cysteine
Ornipural®
pomegranate peel
Kurumlar
Cumhuriyet Üniversitesi
Sivas Turkey
Dicle Üniversitesi
Diyarbakir Turkey
Harran Üniversitesi
Sanliurfa Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
2
Atıf
7
Yazar
5
Anahtar Kelime