Scopus
YÖKSİS Eşleşti
Carvacrol alleviates acrylamide-induced hepatotoxicity in rats: An Experimental insights
Eurasian Journal of Veterinary Sciences · Aralık 2023
YÖKSİS Kayıtları
Carvacrol alleviates acrylamide-induced hepatotoxicity in rats: An Experimental insights
Eurasian Journal of Veterinary Sciences · 2023 Zoological Record
DOÇENT MEHMET BURAK ATEŞ →
Carvacrol alleviates acrylamide-induced hepatotoxicity in rats: An Experimental insights
Eurasian Journal of Veterinary Sciences · 2023 Zoological Record
DOÇENT DURMUŞ HATİPOĞLU →
Makale Bilgileri
DergiEurasian Journal of Veterinary Sciences
Yayın TarihiAralık 2023
Cilt / Sayfa39 · 177-184
Scopus ID2-s2.0-105011260348
Özet
Aim: This study aimed to investigate the protective effects of carvacrol (CRV) on rat liver against acrylamide (AA)-induced hepatotoxicity. Materials and Methods: A total of 30 Wistar Albino rats were used in the study. Rats were divided into 4 groups: Control (n:6), CRV (n:8, 50 mg/kg/ day carvacrol, i.p), AA (n:8, 40 mg/kg/day acrylamide, gavage) and AA+CRV (n:8, 40 mg/kg/day acrylamide, gavage + 50 mg/kg/day carvacrol i.p). At the end of the 15-day study period, the rats, whose blood samples were taken under anesthesia, were euthanized and necropsied. Liver function tests were examined from serums. At the same time for histological analysis, scoring, and hematoxylin-eosin staining, liver tissues were preserved in 10% formaldehyde solution. Results: In microscopic examination, it was determined that AA causes hydropic/vacuolar degeneration, fatty changes, necrosis/apoptosis, bile duct proliferation, hepatic cord dissociation, congestion, megalocytosis and mononuclear cell infiltration. Parallelly, AA raised the levels of ALP, AST, and ALT. The inclusion of CRV to the diet improved histological structure and liver function tests considerably. These results show that CRV has a hepatoprotective effect by reducing AA-induced liver damage. Conclusion: This study showed that CRV attenuated AA-induced liver injury. It is considered that its preventive effect against liver damage is due to its antioxidant properties. However, more research is needed to determine the specific mechanism at the molecular level and offer therapeutic management suggestions.
Yazarlar (4)
1
Aysegul Bulut
2
Goktug Senturk
3
Durmus Hatipoglu
ORCID: 0000-0003-3790-7821
4
Mehmet Burak Ates
ORCID: 0000-0003-1297-426X
Anahtar Kelimeler
Antioxidants
hepatoprotective
liver
oxidative stress
thyme
Kurumlar
Aksaray Üniversitesi
Aksaray Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
4
Atıf
4
Yazar
5
Anahtar Kelime