Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q4
Histopathological evaluation of the effects of thymoquinone and resveratrol on the liver in rats administered doxorubicin
Eurasian Journal of Veterinary Sciences · Eylül 2022
YÖKSİS Kayıtları
Histopathological evaluation of the effects of thymoquinone and resveratrol on the liver in rats administered doxorubicin
Eurasian J Vet Sci · 2022 scopus, cabi, Google scholar, sci, zoological record
Prof. Dr. ÖZGÜR ÖZDEMİR →
Histopathological evaluation of the effects of thymoquinone and resveratrol on the liver in rats administered doxorubicin
Eurasian Journal of Veterinary Sciences · 2022 TR DİZİN
Prof. Dr. MUSTAFA NUMAN BUCAK →
Histopathological evaluation of the effects of thymoquinone and resveratrol on the liver in rats administered doxorubicin
Eurasian Journal of Veterinary Sciences · 2022 Zoological Record
Doç. Dr. MEHMET BURAK ATEŞ →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Serological and virological investigation of bovine viral diarrhea virus infection in cattle with abortion problem
2013 ISSN: 1309-6958 ULAKBİM-YAŞAM BİLİMLERİ
Prof. Dr. OĞUZHAN AVCI →
Antibody prevalence against respiratory viruses in naturally infected cattle in Central Anatolia
2014 ISSN: 1309-6958 ULAKBİM-YAŞAM BİLİMLERİ
Prof. Dr. OĞUZHAN AVCI →
Disseminated metastatic transmissible venereal tumour in a bitch
2013 ISSN: 1309-6958 TR DİZİN 1 atıf
Prof. Dr. MEHMET MADEN →
Investigation on Listeria spp. in Patrige Meat
2014 ISSN: 1309-6958 ULAKBİM TR DİZİN, CAB Abstracts, Index Copernicus
Prof. Dr. GÜRKAN UÇAR →
Pastörize sıvı yumurta ile kabuklu yumurtanın bazı kalite özellikleri bakımından kıyaslanması
2015 ISSN: 1309-6958 ULAKBİM TR DİZİN, CAB Abstracts, Index Copernicus
Prof. Dr. AHMET GÜNER →
Barınak Köpeklerinde Canine Coronavirus Varlığının Belirlenmesi
2015 ISSN: 1309-6958 TR DİZİN
Doç. Dr. IRMAK DİK →
Microbiological quality of red meat pieces
2015 ISSN: 1309-6958 Türkiye Atıf Dizini *EBSCO-HOST*Cab Abstracts*Veterinary Bulletin*Veterinary Science Database*Index Veterinarius*Dairy Science Abstracts *Animal Breeding Abstracts*Agricultural Engineering Abstracts *Global Health*World Agricultural Economics and Rural Sociology Abstracts *Forest Products Abstracts
Prof. Dr. ÜMİT GÜRBÜZ →
Nerium Oleander Distilatının Antimikrobiyal Etkisinin Araştırılması
2013 ISSN: 1309-6958 TR DİZİN
Prof. Dr. BURAK DİK →
Doksorubisinin neden olduğu organ hasarlarında Nerium Oleander distilatının koruyucu etkinliğinin belirlenmesi
2014 ISSN: 1309-6958 TR DİZİN
Prof. Dr. BURAK DİK →
Koyunlarda Tarantula cubensis alkolik ekstraktının (Theranekron) serum tiyobarbitürik asit reaktif ürünlerine etkisi
2014 ISSN: 1309-6958 TR DİZİN
Prof. Dr. BURAK DİK →
Pathological and microbiological investigations on the lesions of the respiratory systems of laying hens
2008 ISSN: 1309-6958 *TÜBİTAK-ULAKBİM-YAŞAM BİLİMLERİ *Türkiye Atıf Dizini *EBSCO-HOST *Cab Abstracts *Veterinary Bulletin *Veterinary Science Database *Index Veterinarius *Dairy Science Abstracts *Animal Breeding Abstracts *Agricultural Engineering Abstracts *Global Health *World Agricultural Economics and Rural Sociology Abstracts *Forest Products Abstracts *Grasslands and Forage Abstracts *Helminthological Abstracts *Rural Development Abstracts *Soils and Fertilizers *Soybean Abstracts *Sugar Industry Abstracts *Tropical Disaeases Bulletin *Wheat, Barley and Tritacale Abstracts *Maize Abstracts
Prof. Dr. ÖZGÜR ÖZDEMİR →
The retrospective evaluations of the neoplastic cases of dog between 2006 to 2011
2013 ISSN: 1309-6958 *TÜBİTAK-ULAKBİM-YAŞAM BİLİMLERİ*Türkiye Atıf Dizini*EBSCO-HOST*Cab Abstracts*Veterinary Bulletin*Veterinary Science Database*Index Veterinarius*Dairy Science Abstracts*Animal Breeding Abstracts*Agricultural Engineering Abstracts*Global Health*World Agricultural Economics and Rural Sociology Abstracts*Forest Products Abstracts*Grasslands and Forage Abstracts*Helminthological Abstracts*Rural Development Abstracts*Soils and Fertilizers*Soybean Abstracts*Sugar Industry Abstracts*Tropical Disaeases Bulletin*Wheat, Barley and Tritacale Abstracts*Maize Abstracts
Prof. Dr. ÖZGÜR ÖZDEMİR →
Bir İnekte Melanom Olgusu
2006 ISSN: 1309-6958 *TÜBİTAK-ULAKBİM-YAŞAM BİLİMLERİ*Türkiye Atıf Dizini*EBSCO-HOST*Cab Abstracts*Veterinary Bulletin*Veterinary Science Database*Index Veterinarius*Dairy Science Abstracts*Animal Breeding Abstracts*Agricultural Engineering Abstracts*Global Health*World Agricultural Economics and Rural Sociology Abstracts*Forest Products Abstracts*Grasslands and Forage Abstracts*Helminthological Abstracts*Rural Development Abstracts*Soils and Fertilizers*Soybean Abstracts*Sugar Industry Abstracts*Tropical Disaeases Bulletin*Wheat, Barley and Tritacale Abstracts*Maize Abstracts
Prof. Dr. ÖZGÜR ÖZDEMİR →
Ham ayçiçek yağı yerine yan ürünlerinin yumurta tavuklarında enerji kaynağı olarak kullanımı
1994 ISSN: 1309 - 6958 TR DİZİN
Prof. Dr. TAHİR BALEVİ →
Serbest ve korunmuş formdaki asit yağın süt ineklerinde rumen fermentasyonu ve süt verimi üzerine etkileri
2000 ISSN: 1309 - 6958 TR DİZİN
Prof. Dr. HUZUR DERYA ARIK →
Geçiş dönemindeki süt ineklerinde gliserol kullanımının etkileri
2010 ISSN: 1309 - 6958 TR DİZİN
Prof. Dr. TAHİR BALEVİ →
Bazı et ürünlerinde E coli O157 H7 varlığının araştırılması
2010 ISSN: 1309-6958 EBSCO-HOST*Cab Abstracts*Veterinary Bulletin*Veterinary Science Database*Index Veterinarius 1 atıf
Prof. Dr. ÜMİT GÜRBÜZ →
Karaman ilinde yetiştirilen koyunlarda Blue Tongue Virus enfeksiyonunun serolojik olarak araştırılması
2015 ISSN: 1309-6958 TÜBİTAK Yaşam Bilimleri, CAB Abstracts, Vet Bull, EBSCO, Vet Sci Database vs...
Prof. Dr. ATİLLA ŞİMŞEK →
Yerli merkeplerde vena portae’nın karaciğer içerisindeki dağılımı üzerine makroanatomik araştırmalar
2014 ISSN: 1309-6958 Cab Abstract
Prof. Dr. MUSTAFA ORHUN DAYAN →
Makale Bilgileri
ISSN13096958
Yayın TarihiEylül 2022
Cilt / Sayfa38 · 150-158
Scopus ID2-s2.0-105011293360
Erişim🔓 Açık Erişim
Özet
Aim: The purpose was to investigate the effects of various dosages of thymoquinone and resveratrol (5 and 20 mg/kg) on doxorubicin-induced hepatotoxicity in rats from a pathological standpoint. Materials and Methods: Eighty male Wistar Albino rats were used in this study. Animals were divided in to 10 groups: Control (physiological saline, PO); Doxorubicin (physiological saline, PO and Dox,15mg/kg Dox in 10th days, IP); Thymoquinone -5 (TQ-5, 5 mg/kg TQ, PO); TQ-20 (20 mg/ kg TQ, PO); Resveratrol-5 (Res-5, 5 mg/kg Res, PO); Res-20 (20 mg/kg Res, PO); Dox+TQ-5; Dox+TQ-20; Dox+Res-5; Dox+Res-20. After the 21-day experiment, 6 replicates were randomly selected from the groups. After weighing the body weight, the livers of the euthanized rats were dissected and weighed. Routine tissue processing processes were applied to liver samples. Hepatocyte degeneration, necrosis/apoptosis, bile duct hyperplasia, dissociation, congestion, karyomegaly, mononuclear cell infiltration, binuclear hepatocytes, and mitosis were all examined microscopically, and a liver total lesion score was calculated Results: Dox treatment increased relative liver weight, but the TQ and Res groups prevented this increase (p<0.05). The liver total lesion score, which increased with Dox, was shown to be lower in the TQ and Res groups (p<0.05). However, the Dox+TQ-5, Dox+TQ-20, and Dox+Res-20 groups, showed no amelioration in necrosis/apoptosis. Conclusion: TQ and Res (5 and 20 mg/kg) decreased the total liver lesion score induced by Dox. Although TQ and RES diminish degeneration and inflammation, their poor protective effects on necrosis/apoptosis, one of the key criteria, were considered as a limiting cause for their uncontrolled usage.
Yazarlar (5)
1
Mehmet Burak Ates
ORCID: 0000-0003-1297-426X
2
O. Ozdemir
3
Ali Erdem Öztürk
4
Mustafa Numan Bucak
5
Aysegul Bulut
Anahtar Kelimeler
doxorubicin
histopathology
Liver
resveratrol
thymoquinone
Kurumlar
Erciyes Üniversitesi
Kayseri Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Eurasian Journal of Veterinary Sciences
Q4
OA
SJR Skoru0,178
H-Index5
YayıncıSelcuk Universitesi, Veteriner Fakultesi
ÜlkeTurkey
Veterinary (miscellaneous) (Q4)
Metrikler
3
Atıf
5
Yazar
5
Anahtar Kelime