Scopus
YÖKSİS Eşleşti
Histopathological evaluation of the effects of thymoquinone and resveratrol on the liver in rats administered doxorubicin
Eurasian Journal of Veterinary Sciences · Eylül 2022
YÖKSİS Kayıtları
Histopathological evaluation of the effects of thymoquinone and resveratrol on the liver in rats administered doxorubicin
Eurasian Journal of Veterinary Sciences · 2022 TR DİZİN
PROFESÖR MUSTAFA NUMAN BUCAK →
Histopathological evaluation of the effects of thymoquinone and resveratrol on the liver in rats administered doxorubicin
Eurasian Journal of Veterinary Sciences · 2022 Zoological Record
DOÇENT MEHMET BURAK ATEŞ →
Histopathological evaluation of the effects of thymoquinone and resveratrol on the liver in rats administered doxorubicin
Eurasian J Vet Sci · 2022 scopus, cabi, Google scholar, sci, zoological record
PROFESÖR ÖZGÜR ÖZDEMİR →
Makale Bilgileri
DergiEurasian Journal of Veterinary Sciences
Yayın TarihiEylül 2022
Cilt / Sayfa38 · 150-158
Scopus ID2-s2.0-105011293360
Özet
Aim: The purpose was to investigate the effects of various dosages of thymoquinone and resveratrol (5 and 20 mg/kg) on doxorubicin-induced hepatotoxicity in rats from a pathological standpoint. Materials and Methods: Eighty male Wistar Albino rats were used in this study. Animals were divided in to 10 groups: Control (physiological saline, PO); Doxorubicin (physiological saline, PO and Dox,15mg/kg Dox in 10th days, IP); Thymoquinone -5 (TQ-5, 5 mg/kg TQ, PO); TQ-20 (20 mg/ kg TQ, PO); Resveratrol-5 (Res-5, 5 mg/kg Res, PO); Res-20 (20 mg/kg Res, PO); Dox+TQ-5; Dox+TQ-20; Dox+Res-5; Dox+Res-20. After the 21-day experiment, 6 replicates were randomly selected from the groups. After weighing the body weight, the livers of the euthanized rats were dissected and weighed. Routine tissue processing processes were applied to liver samples. Hepatocyte degeneration, necrosis/apoptosis, bile duct hyperplasia, dissociation, congestion, karyomegaly, mononuclear cell infiltration, binuclear hepatocytes, and mitosis were all examined microscopically, and a liver total lesion score was calculated Results: Dox treatment increased relative liver weight, but the TQ and Res groups prevented this increase (p<0.05). The liver total lesion score, which increased with Dox, was shown to be lower in the TQ and Res groups (p<0.05). However, the Dox+TQ-5, Dox+TQ-20, and Dox+Res-20 groups, showed no amelioration in necrosis/apoptosis. Conclusion: TQ and Res (5 and 20 mg/kg) decreased the total liver lesion score induced by Dox. Although TQ and RES diminish degeneration and inflammation, their poor protective effects on necrosis/apoptosis, one of the key criteria, were considered as a limiting cause for their uncontrolled usage.
Yazarlar (5)
1
Mehmet Burak Ates
ORCID: 0000-0003-1297-426X
2
O. Ozdemir
3
Ali Erdem Öztürk
4
Mustafa Numan Bucak
5
Aysegul Bulut
Anahtar Kelimeler
doxorubicin
histopathology
Liver
resveratrol
thymoquinone
Kurumlar
Erciyes Üniversitesi
Kayseri Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
2
Atıf
5
Yazar
5
Anahtar Kelime