Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Contribution of ellagic acid on the antioxidant potential of medicinal plant Epilobium hirsutum
Nutrition and Cancer · Ocak 2016
YÖKSİS Kayıtları
Contribution of ellagic acid on the antioxidant potential of medicinal plant Epilobium hirsutum
Nutrition and Cancer · 2016 SCI-Expanded
Prof. Dr. SERDAR KARAKURT →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Contribution of ellagic acid on the antioxidant potential of medicinal plant Epilobium hirsutum
2016 ISSN: 0163-5581 SCI-Expanded
Prof. Dr. SERDAR KARAKURT →
Identification of Potential Therapeutic Genes and Pathways in Phytoestrogen Emodin Treated Breast Cancer Cell Lines via Network Biology Approaches
2022 ISSN: 0163-5581 SCI Q3
Dr. Öğr. Üyesi PEMBEGÜL UYAR ARPACI →
Makale Bilgileri
Dergi
Nutrition and Cancer
ISSN01635581
Yayın TarihiOcak 2016
Cilt / Sayfa68 · 173-183
Scopus ID2-s2.0-84957965445
Özet
In the present study, the possible role of ellagic acid (EA) on antioxidant potential of Epilobium hirsutum (EH) in rat liver was investigated. Wistar rats were intraperitoneally treated with 37.5 mg/kg of EH and 10 mg/kg of EA for 9 days. Effects of EH and EA on antioxidant [glutathione peroxidase (GPx) and superoxide dismutases (SOD)] and Phase II [NADPH quinone oxidoreductase 1 (NQO1) and glutathione S-transferases (GSTs)] enzyme activities, as well as protein and mRNA expressions of those, were investigated. Polyphenolic content of EH was determined by LC-MS/MS analysis. EH and EA injection to rats resulted in a significant increase of NQO1 (3.6-fold and 4.7-fold), GPx (1.45-fold), and SOD (1.34-fold and 1.27-fold) enzyme activities, whereas total GST (46% and 57%) and its isoforms,and GST mu (57% and 72%), and GST theta (60% and 68%) activities were significantly decreased. Western-blot and qRT-PCR analysis showed that NQO1 and GPx protein and mRNA expressions were increased significantly (P < 0.0001), whereas GST mu and GST theta were significantly decreased (P < 0.0001).
Yazarlar (6)
1
Serdar Karakurt
2
Asli Semiz
3
Gurbet Celik
4
Ayse Mine Gencler-Ozkan
5
Alaattin Sen
6
Orhan Adali
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Middle East Technical University (METU)
Ankara Turkey
Pamukkale Üniversitesi
Denizli Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Nutrition and Cancer
Q2
SJR Skoru0,706
H-Index137
YayıncıTaylor and Francis Ltd.
ÜlkeUnited States
Medicine (miscellaneous) (Q2)
Nutrition and Dietetics (Q2)
Cancer Research (Q3)
Oncology (Q3)
Metrikler
22
Atıf
6
Yazar