Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
Cytotoxic activities of methanol extract and compounds of Porodaedalea pini against colorectal cancer
International Journal of Secondary Metabolite · Mart 2021
YÖKSİS Kayıtları
Cytotoxic Activities of Methanol Extract and Compounds of Porodaedalea pini Against Colorectal Cancer
International Journal of Secondary Metabolite · 2021 Biyokimya
Prof. Dr. SERDAR KARAKURT →
Makale Bilgileri
Dergi
International Journal of Secondary Metabolite
Yayın TarihiMart 2021
Cilt / Sayfa8 · 40-48
Scopus ID2-s2.0-85105454783
Erişim🔓 Açık Erişim
Özet
Porodaedalea pini is a medicinally important mushroom with antioxidant, cytotoxic, immunostimulating, antitumor, antiviral and immunomodulating activities. Therefore, in this study, P. pini methanol extract and isolated compounds from the methanol extract were tested for cytotoxic activities against DLD-1 (colorectal cancer) and CCD-18Co (human colon fibroblast cell line) by using Alamar Blue assay. Cytotoxic activity on DLD-1 was decreased in the order of P. pini methanol extract> 4-(3,4-dihydroxyphenyl)but-3-en-2-one (3)> pinoresinol (2)> ergosta-7,24(28)-dien-3β-ol (1). P. pini methanol extract was determined to have the best cytotoxic activity with the lowest IC<inf>50</inf> value on DLD-1 (IC<inf>50</inf>: 25.33±0.29 µg/mL) and the highest IC<inf>50</inf> value on CCD-18Co (434.30±1.45 µg/mL). Within the scope of the findings, it is thought that P. pini mushroom can be used as a new and natural agent in the treatment of colorectal cancer.
Yazarlar (4)
1
Ebru Deveci
2
Gülsen Tel-Çayan
ORCID: 0000-0002-1916-7391
3
Serdar Karakurt
4
Mehmet Emin Duru
ORCID: 0000-0001-7252-4880
Anahtar Kelimeler
Colorectal cancer
Cytotoxic activity
Extract
Isolation
Porodaedalea pini
Kurumlar
Konya Technical University
Konya Turkey
Muğla Sıtkı Koçman Üniversitesi
Mugla Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
7
Atıf
4
Yazar
5
Anahtar Kelime