Scopus
🔓 Açık Erişim
Tannic acid elicits differential gene regulation in prostate cancer apoptosis
Acta Pharmaceutica Zagreb Croatia · Eylül 2024
Makale Bilgileri
DergiActa Pharmaceutica Zagreb Croatia
Yayın TarihiEylül 2024
Cilt / Sayfa74 · 539-550
Scopus ID2-s2.0-85204167685
Erişim🔓 Açık Erişim
Özet
Prostate cancer is a significant global health concern that requires innovative therapeutic investigations. Here, the potential anticancer properties of tannic acid were evaluated by examining its effects on apoptosis in prostate cancer cell lines. PC-3 and LnCaP prostate adeno carcinoma cells, along with PNT1A prostate control cells, were cultured and divided into untreated and tannic acid-treated groups. Cell proliferation, cytotoxicity, and effects of tannic acid on the cell death mechanism were evaluated. mRNA expression levels of 84 genes were explored in cells following tannic acid treatment. Notably, tannic acid-induced down-regulation of several pro-survival genes, including ATM, BCL2, BCL2A1, BIK, BIRC2, BIRC3, BRE, CASP3, CASP6, CASP8, CHEK2, CRADD, PPIA, RPA3, TNFSF18, TRAF1, TRAF2, TRAF4, and TRAF5 in both cell lines. Moreover, tannic acid treatment led to the up-regulation of various pro-apoptotic genes, such as BCL10, BIRC3, BNIP3, CASP1, CASP5, CD40, CIDEB, DAPK2, FASLG, GADD45A, MYD88, RPA 3, TNFRSF10D, TNFRSF17, TNFRSF8, TNFSF13B, TNFSF4, TNFSF7, TNFSF8, TNFSF9, TP53, TRAF1, and TRAF2 in both PC-3 and LnCap cells. These findings highlight tannic acid's ability to induce apoptosis in prostate cancer cells through pro-apoptotic pathways. This study concludes that tannic acid selectively inhibits prostate cancer cell growth.
Yazarlar (4)
1
Sinan Kandir
2
Sevtap Karakurt
ORCID: 0000-0001-7211-1285
3
Çiğdem Gökçek-Saraç
ORCID: 0000-0002-3538-6551
4
Serdar Karakurt
Anahtar Kelimeler
apoptosis
gene regulation
prostate cancer
selective cytotoxicity
tannic acid
Kurumlar
Akdeniz Üniversitesi
Antalya Turkey
Çukurova Üniversitesi
Adana Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
2
Atıf
4
Yazar
5
Anahtar Kelime