Scopus
YÖKSİS Eşleşti
Apoptosis-induced T-cell lymphopenia is related to COVID-19 severity
Journal of Medical Virology · Mayıs 2021
YÖKSİS Kayıtları
Apoptosis-induced T-cell lymphopenia is related to COVID-19 severity
Journal of Medical Virology · 2021 SCI-Expanded
PROFESÖR HASİBE ARTAÇ →
Apoptosis induced T-cell lymphopenia is related to COVID-19 severity
Journal of Medical Virology · 2021 SCI-Expanded
DOÇENT AHMET ÇİZMECİOĞLU →
Makale Bilgileri
DergiJournal of Medical Virology
Yayın TarihiMayıs 2021
Cilt / Sayfa93 · 2867-2874
Scopus ID2-s2.0-85101198780
Özet
Increased levels of acute-phase reactants and lymphopenia are predictors of disease severity in coronavirus disease 2019 (COVID-19). This study aimed to investigate the role of apoptosis in the etiology of lymphopenia in patients with COVID-19. This multicentered, prospective, and case-control study was conducted with polymerase chain reaction (+) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients, and an age–gender-matched control group. Samples were taken at the time of diagnosis and analyzed via flow cytometry within 24 h. The participants' demographic data and initial laboratory tests were also recorded. In total, 33 patients with COVID-19 (mean age = 45.4 ± 17.2) and 25 controls (mean age = 43.4 ± 17.4) participated in the study. All patients were identified as having mild (16), moderate (5), or severe (12) disease severity. Both early and late apoptotic cells in B and T lymphocytes were increased in all patients with COVID-19 (p <.05). Early apoptotic (EA) B and T lymphocytes were also higher in severe cases compared to mild cases (p =.026). There was no significant difference between lymphopenia and apoptosis in patients with COVID-19. However, patients with lymphopenia (n = 14) and severe COVID-19 (p =.013) had increased EA T lymphocytes. This study's results show that B and T lymphocytes' apoptosis increases in patients with COVID-19. In addition, enhanced T lymphocyte apoptosis is associated with disease severity in lymphopenic patients with COVID-19.
Yazarlar (8)
1
Ahmet Cizmecioglu
2
Hilal Cizmecioglu
3
Mevlut Hakan Goktepe
4
Ayca Emsen
ORCID: 0000-0003-3028-3112
5
Celalettin Korkmaz
ORCID: 0000-0001-8602-0368
6
Fatma Esenkaya Taşbent
7
Fatma Colkesen
ORCID: 0000-0001-9545-5179
8
Hasibe Artac
Anahtar Kelimeler
apoptosis
COVID-19
disease severity
lymphopenia
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Tip Fakültesi
Konya Turkey
University of Health Sciences
Istanbul Turkey
Metrikler
50
Atıf
8
Yazar
4
Anahtar Kelime