Scopus
YÖKSİS Eşleşti
Treatment of Acute Vocal Fold Injury With Platelet-Rich Plasma
Journal of Voice · Kasım 2016
YÖKSİS Kayıtları
Treatment of Acute Vocal Fold Injury With Platelet-Rich Plasma
Journal of Voice · 2016 SCI-Expanded
DOÇENT ÇAĞDAŞ ELSÜRER →
Treatment of Acute Vocal Fold Injury With Platelet Rich Plasma
Journal of Voice · 2016 SCI-Expanded
DOÇENT ÇAĞDAŞ ELSÜRER →
Makale Bilgileri
DergiJournal of Voice
Yayın TarihiKasım 2016
Cilt / Sayfa30 · 731-735
Scopus ID2-s2.0-84939159830
Özet
Objectives Platelet-rich plasma (PRP) is a reliable and has low side-effect profile and has beneficial effects on wound healing. Its investigatory effects on wound-healing process were shown on various tissues. The aim of the present study was to evaluate effectiveness of PRP application on scar tissue of acute vocal fold injury. Materials and methods Twenty-four Wistar rats were used in the study. The entire layer of the lamina propria down to the thyroarytenoid muscle of 10 subjects was unilaterally injured by with a microscissor. Gelfoam-absorbed PRP was applied on the injured area for 10 minutes. Control group consisted of rats unilaterally injured using a microscissor, and gelfoam with normal saline was applied on the injured area. Following sacrifice, the larynxes were carefully dissected and removed for histopathologic examination. After excised larynx experiments, serial sections were prepared from vocal fold. Hematoxylin eosin and immunohistochemical staining were done for epithelial growth factor receptor (EGFR), fibroblast growth factor receptor (FGFR1), and vascular endothelial growth factor (VEGF) staining for histopathologic examinations. Results There was not a significant difference between the two groups for lymphocyte. Although collagen and VEGF were higher in the study group, there was not a significant difference between the groups (P > 0.05). There was a significant difference between control and study groups for EGFR and FGFR1(P < 0.05). Conclusions PRP has beneficial effects on wound healing. PRP accelerates epithelization of injured rat vocal folds by inducing EGFR secretion. PRP is an autogenous, reliable, low side-effect profile, easily harvested material. PRP may be useful to prevent scar formation.
Yazarlar (7)
1
Serap Bulut Cobden
2
Kayhan Öztürk
3
Selcuk Duman
4
Hasan Esen
5
Tahsin Murad Aktan
6
Mustafa Avunduk
7
Çağdaş Elsürer
ORCID: 0000-0001-9804-7023
Anahtar Kelimeler
EGFR
FGFR1
Injury
PRP
Scar
VEGF
Vocal fold
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
27
Atıf
7
Yazar
7
Anahtar Kelime