Scopus
YÖKSİS Eşleşti
The role of regulatory T cells in allergic rhinitis and their correlation with IL-10, IL-17 and neopterin levels in serum and nasal lavage fluid
European Archives of Oto Rhino Laryngology · Nisan 2020
YÖKSİS Kayıtları
The role of regulatory T cells in allergic rhinitis and their correlationwith IL‑10, IL‑17 and neopterin levels in serum and nasal lavage fluid
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY · 2020 SCI-Expanded
PROFESÖR METE KAAN BOZKURT →
The role of regulatory T cells in allergic rhinitis and their correlationwith IL‑10, IL‑17 and neopterin levels in serum and nasal lavage fluid
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY · 2020 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
The role of regulatory T cells in allergic rhinitis and their correlationwith IL‑10, IL‑17 and neopterin levels in serum and nasal lavage fluid
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY · 2020 SCI-Expanded
PROFESÖR HASİBE ARTAÇ →
Makale Bilgileri
DergiEuropean Archives of Oto Rhino Laryngology
Yayın TarihiNisan 2020
Cilt / Sayfa277 · 1109-1114
Scopus ID2-s2.0-85078720192
Özet
Purpose: Allergic rhinitis (AR), is an IgE-mediated inflammation of the nose. Regulatory T cells (Tregs) and inflammatory cytokines have been shown to play a critical role in allergic airway inflammation. The aim of the study was to compare the levels of blood T lymphocyte subsets and IL-10, IL-17 and neopterin concentrations in serum and nasal lavage of patients with AR compared to healthy subjects. Methods: The study included 38 subjects with moderate-severe AR and 36 sex- and age-matched controls. Peripheral blood CD3+, CD3+CD4+ and CD4+CD25+Foxp3 percentages were evaluated using flow cytometry. Levels of IL-10, IL-17 and neopterin were measured both in serum and nasal lavage fluid with ELISA and HPLC, respectively. Results: No difference was found in the percentages of T lymphocyte subsets between the two groups (p > 0.05). Serum IL-10 levels were similar (p > 0.05), whereas nasal IL-10 was lower in AR subjects compared to control group (2.22 ± 0.91 and 3.12 ± 1.45 pg/ml, respectively) (p < 0.05). Mean serum and nasal IL-17 were higher in AR (107.7 ± 79.61 and 527.36 ± 738.7 pg/ml) than the control group (76.29 ± 28.94 and 328.9 ± 430.8 pg/ml) (p < 0.05 and p > 0.05). There were no significant differences in serum and nasal neopterin levels (p > 0.05). Conclusions: Although there were no differences in the distribution of lymphocyte subsets between the AR and control groups, the finding of higher levels of serum and nasal IL-17 and lower levels of nasal IL-10 support the cytokine imbalance in the pathogenesis of AR.
Yazarlar (7)
1
Kadriye Erkan
2
Mete Kaan Bozkurt
ORCID: 0000-0002-3153-3294
3
Hasibe Artac
4
Hulya Ozdemir
5
Ali Ünlü
ORCID: 0000-0002-9991-3939
6
Emine N. Korucu
7
Çağdaş Elsürer
ORCID: 0000-0001-9804-7023
Anahtar Kelimeler
Allergic rhinitis
IL-10
IL-17
Neopterin
Regulatory T cells
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Otolaryngology Department
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
15
Atıf
7
Yazar
5
Anahtar Kelime