Scopus
YÖKSİS Eşleşti
Impact of Pre-transplant and Post-transplant Remission Status of Patients on Survival in Newly Diagnosed Multiple Myeloma
Indian Journal of Hematology and Blood Transfusion · Ekim 2019
YÖKSİS Kayıtları
Impact of Pre-transplant and Post-transplant Remission Status of Patients on Survival in Newly Diagnosed Multiple Myeloma
Indian Journal of Hematology and Blood Transfusion · 2019 SCI-Expanded
PROFESÖR RAFİYE ÇİFTÇİLER →
Makale Bilgileri
DergiIndian Journal of Hematology and Blood Transfusion
Yayın TarihiEkim 2019
Cilt / Sayfa35 · 655-661
Scopus ID2-s2.0-85062711151
Özet
The overall survival (OS) in patients with multiple myeloma (MM) has increased in the last decade due to the introduction of proteasome inhibitors, immunomodulatory drugs and monoclonal antibodies as well as an extensive combination of autologous stem cell transplantation (ASCT) for suitable patients. The objective of this study was to examine the impact of pre-transplant and post-transplant remission status of patients on survival in newly diagnosed multiple myeloma. Two hundred and four patients with newly diagnosed MM who received an ASCT in our HSC transplant center at Hacettepe University Hospital between the years of 2001 and 2018 were evaluated in a retrospective manner. The median follow-up period was 35.9 months (range 4.2–206.4) for the entire group. The 5-year OS for pre-transplant remission status CR/VGPR patients and pre-transplant remission status PR or less patients were 79% and 68%, respectively (p = 0.09). The 5-year PFS for pre-transplant remission status CR/VGPR patients and pre-transplant remission status PR or less patients were 62% and 45%, respectively (p = 0.23). The 5-year OS for post-transplant remission status CR/VGPR group was 72% and for post-transplant remission status PR or less group was 60% (p = 0.02). The 5-year PFS in post-transplant remission status CR/VGPR patients was 48% and post-transplant remission status PR or less patients was 36% (p = 0.03). This study focuses on determination of survival outcome based on the best response obtained before and after ASCT and particularly highlights the significance of reaching CR and VGPR.
Yazarlar (5)
1
Rafiye Çiftçiler
ORCID: 0000-0001-5687-8531
2
Hakan Göker
3
Yahya Büyükaşık
4
Elifcan Aladag
5
Haluk Demiroğlu
Anahtar Kelimeler
Complete remission
Multiple myeloma
Remission status
Very good partial response
Kurumlar
Hacettepe Üniversitesi
Ankara Turkey
Metrikler
1
Atıf
5
Yazar
4
Anahtar Kelime