Scopus
YÖKSİS DOI Eşleşti
SJR Q2
The comparison of bone marrow kinetics between patients with acute myeloid leukemia and acute promyelocytic leukemia after induction chemotherapy
Immunopharmacology and Immunotoxicology · Ocak 2020
YÖKSİS Kayıtları
The comparison of bone marrow kinetics between patients with acute myeloid leukemia and acute promyelocytic leukemia after induction chemotherapy
Immunopharmacology and Immunotoxicology · 2020 SCI-Expanded
Prof. Dr. RAFİYE ÇİFTÇİLER →
YÖKSİS Kayıtları — ISSN Eşleşmesi
The comparison of bone marrow kinetics between patients with acute myeloid leukemia and acute promyelocytic leukemia after induction chemotherapy
2020 ISSN: 0892-3973 SCI-Expanded
Prof. Dr. RAFİYE ÇİFTÇİLER →
Makale Bilgileri
ISSN08923973
Yayın TarihiOcak 2020
Cilt / Sayfa42 · 17-21
Scopus ID2-s2.0-85075204888
Özet
Background and Aim: Recently, acute promyelocytic leukemia (APL) has shifted from the most hazardous to the best curable type of acute myeloid leukemia. Anthracyclines, all-trans retinoic acid (ATRA) and arsenic derivatives are the most important developments for the treatment of APL. ATRA promotes the terminal differentiation of malignant promyelocytes to mature neutrophils. We aimed to compare platelet and neutrophil recovery time after induction chemotherapy in patients with acute myeloid leukemia (AML) and APL. Materials and Methods: Two hundred and fifteen patients with AML and APL, who were diagnosed and treated in our tertiary care center between the years of 2001 and 2018 were evaluated. Results: One hundred and eighty one AML patients (84.2%) and 34 (15.8%) APL patients were included in this study. The time between neutrophil nadir after induction chemotherapy and neutrophil recovery was longer in APL patients than in AML patients [30.5 (4–52) vs. 20 (5–58), p < 0.001]. The time between platelet nadir after induction chemotherapy and platelet recovery was longer in APL patients than in AML patients [21.5 (4–42) vs. 17 (4–45), p = 0.02]. Conclusion: Neutrophil and platelet recovery times were longer in APL patients than in AML patients in our present study. In 60 days, mortality rate was higher in APL patients than AML patients. Non-relapse mortality (NRM) rate was similar between two groups. There was a significant difference between two groups in terms of NRM causes. Platelet and neutrophil recovery time is very important because infection is the most important cause of NRM.
Yazarlar (8)
1
Rafiye Çiftçiler
ORCID: 0000-0001-5687-8531
2
İbrahim Celalettin Haznedaroğlu
3
Osman Özcebe
4
Salih Aksu
ORCID: 0000-0003-0634-3808
5
Nilgün Sayınalp
6
Hakan Göker
7
Haluk Demiroğlu
8
Yahya Büyükaşık
Anahtar Kelimeler
Acute myloid leukemia
acute promyelocytic leukemia
neutrophil recovery
platelet recovery
Kurumlar
Hacettepe Üniversitesi
Ankara Turkey
Scimago Dergi (ISSN Eşleşmesi)
Immunopharmacology and Immunotoxicology
Q2
SJR Skoru0,723
H-Index67
YayıncıTaylor and Francis Ltd.
ÜlkeUnited Kingdom
Medicine (miscellaneous) (Q2)
Pharmacology (Q2)
Toxicology (Q2)
Immunology (Q3)
Immunology and Allergy (Q3)
Metrikler
2
Atıf
8
Yazar
4
Anahtar Kelime