Assessment of the Prognostic Importance of The Revised International Staging System Based on Plasmacytoma Presentation in Recently Diagnosed Patients with Multiple Myeloma

Indian Journal of Hematology and Blood Transfusion · Ocak 2025

YÖKSİS Kayıtları

Indian Journal of Hematology and Blood Transfusion · 2024 SCI-Expanded

Prof. Dr. RAFİYE ÇİFTÇİLER →

YÖKSİS Kayıtları — ISSN Eşleşmesi

Impact of Pre-transplant and Post-transplant Remission Status of Patients on Survival in Newly Diagnosed Multiple Myeloma

2019 ISSN: 0971-4502 SCI-Expanded

Prof. Dr. RAFİYE ÇİFTÇİLER →

10.1007/s12288-019-01108-7

Acquired Hemophilia A In Adults: A Multicenter Study from Turkey

2023 ISSN: 0971-4502 SCI-Expanded

Prof. Dr. RAFİYE ÇİFTÇİLER →

10.1007/s12288-022-01556-8

Assessment of the Prognostic Importance of The Revised International Staging System Based on Plasmacytoma Presentation in Recently Diagnosed Patients with Multiple Myeloma

2024 ISSN: 0971-4502 SCI-Expanded Q4

Prof. Dr. RAFİYE ÇİFTÇİLER →

10.1007/s12288-024-01820-z

Acquired Hemophilia A In Adults: A Multicenter Study from Turkey

2022 ISSN: 0971-4502 SCI-Expanded

Dr. Öğr. Üyesi CEM SELİM →

10.1007/s12288-022-01556-8

Makale Bilgileri

Dergi Indian Journal of Hematology and Blood Transfusion

ISSN09714502

Yayın TarihiOcak 2025

Cilt / Sayfa41 · 31-37

DOI10.1007/s12288-024-01820-z

Scopus ID2-s2.0-85198060608

Özet The rapid development of fluorescence in situ hybridization (FISH) karyotyping led to the discovery of the significant prognostic impact of certain chromosomal abnormalities on the course of Multiple Myeloma (MM). Additionally, high blood lactate dehydrogenase (LDH) levels have been connected to shorter survival periods, more aggressive malignancies, enhanced cell proliferation, and extramedullary illnesses. This study aims to evaluate the prognostic significance of the R-ISS according to plasmacytoma presentation in newly diagnosed MM patients. Retrospective methods were used to conduct this investigation. A total of 166 consecutive patients with newly diagnosed MM and treated in our tertiary care center between the years 2009 and 2023 were evaluated. Of the 166 individuals who were included in this research, 35 (21.1%) had plasmacytomas at diagnosis. Plasmacytoma was not detected in 131 (78.9%) patients at diagnosis. The mean age was 56.8 ± 7.5 for all patients. The age of the patients without plasmacytoma at diagnosis was statistically significantly higher than patients with plasmacytoma at diagnosis (p: 0.04). No statistically significant difference was observed in terms of OS and DFS in the R-ISS 1, 2, and 3 groups in patients with and without plasmacytoma at diagnosis. Due to this study’s results, we think that more needs to be done regarding the R-ISS classification. Perhaps it would be more effective to include other factors in risk classification, such as age, gender, and the presence of plasmacytoma and lytic lesions.