Scopus
YÖKSİS DOI Eşleşti
SJR Q2
A sensitive amperometric detection of neurotransmitter acetylcholine using carbon dot-modified carbon paste electrode
Biotechnology and Applied Biochemistry · Şubat 2021
YÖKSİS Kayıtları
A sensitive amperometric detection of neurotransmitter acetylcholine using carbon dot-modified carbon paste electrode
Biotechnology and Applied Biochemistry · 2021 SCI-Expanded
Doç. Dr. SALİHA DİNÇ →
A sensitive amperometric detection of neurotransmitter acetylcholine using carbon dot-modified carbon paste electrode
Biotechnology and Applied Biochemistry · 2021 SCI-Expanded
Prof. Dr. MUSTAFA ÖZMEN →
YÖKSİS Kayıtları — ISSN Eşleşmesi
A sensitive amperometric detection of neurotransmitter acetylcholine using carbon dot-modified carbon paste electrode
2021 ISSN: 0885-4513 SCI-Expanded Q3
Doç. Dr. SALİHA DİNÇ →
Makale Bilgileri
ISSN08854513
Yayın TarihiŞubat 2021
Cilt / Sayfa68 · 20-29
Scopus ID2-s2.0-85079707986
Özet
Acetylcholine is a neurotransmitter, which is located at the intersections of the nerve and muscles in the lymph nodes of the internal organs motor systems and in various parts of the central nervous system. A decrease of acetylcholine in brain is associated with Alzheimer‘s disease. That is why it is an important agent for this disease. In this study, a bienzymatic biosensor system with acetylcholine esterase and choline oxidase was prepared with carbon paste electrode modified with carbon nano Dot-(3-Aminopropyl) triethoxysilane (CDs-APTES) for determination of the amount of acetylcholine. Acetylcholine esterase and choline oxidase enzymes were immobilized onto a modified carbon paste electrode by cross-linking with glutaraldehyde. Determination of acetylcholine was carried out by the oxidation of enzymatically produced H<inf>2</inf>O<inf>2</inf> at 0.4 V versus Ag/AgCl. The effect of temperature, pH, and substrate concentration on the acetylcholine response of the prepared biosensor was investigated. In addition, the optimum CDs-APTES amount, the linear operating range of the biosensor, and the interference effect were also investigated.
Yazarlar (4)
1
Onur Can Bodur
2
Saliha Dinç
3
Mustafa Ozmen
ORCID: 0000-0001-5117-9168
4
Fatma Arslan
Anahtar Kelimeler
acetylcholine esterase
biosensor
choline oxidase
Kurumlar
Gazi Üniversitesi
Ankara Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Biotechnology and Applied Biochemistry
Q2
SJR Skoru0,738
H-Index85
YayıncıWiley-Blackwell
ÜlkeUnited States
Applied Microbiology and Biotechnology (Q2)
Bioengineering (Q2)
Biomedical Engineering (Q2)
Biotechnology (Q2)
Drug Discovery (Q2)
Medicine (miscellaneous) (Q2)
Process Chemistry and Technology (Q2)
Molecular Medicine (Q3)
Metrikler
30
Atıf
4
Yazar
3
Anahtar Kelime