Scopus
YÖKSİS Eşleşti
Unveiling the molecular Hallmarks of Peyronie’s disease: a comprehensive narrative review
International Journal of Impotence Research · Aralık 2024
YÖKSİS Kayıtları
Unveiling the molecular Hallmarks of Peyronie’s disease: a comprehensive narrative review
International Journal of Impotence Research · 2024 SCI-Expanded
DOÇENT EMRE ALTINTAŞ →
Unveiling the molecular Hallmarks of Peyronie’s disease: a comprehensive narrative review
International Journal of Impotence Research · 2024 SCI-Expanded
DOÇENT EMRE ALTINTAŞ →
Unveiling the molecular Hallmarks of Peyronie’s disease: a comprehensive narrative review
International Journal of Impotence Research · 2024 SCI-Expanded
DOÇENT MURAT GÜL →
Makale Bilgileri
DergiInternational Journal of Impotence Research
Yayın TarihiAralık 2024
Cilt / Sayfa36 · 801-808
Scopus ID2-s2.0-85186883877
Özet
Peyronie’s disease, a fibroinflammatory disorder, detrimentally impacts the sexual well-being of men and their partners. The manifestation of fibrotic plaques within penile tissue, attributed to dysregulated fibrogenesis, is pathognomonic for this condition. The onset of fibrosis hinges on the perturbation of the equilibrium between matrix metalloproteinases (MMPs), crucial enzymes governing the extracellular matrix, and tissue inhibitors of MMPs (TIMPs). In the context of Peyronie’s disease, there is an elevation in TIMP levels coupled with a decline in MMP levels, culminating in fibrogenesis. Despite the scant molecular insights into fibrotic pathologies, particularly in the context of Peyronie’s disease, a comprehensive literature search spanning 1995 to 2023, utilizing PubMed Library, was conducted to elucidate these mechanisms. The findings underscore the involvement of growth factors such as FGF and PDGF, and cytokines like IL-1 and IL-6, alongside PAI-1, PTX-3, HIF, and IgG4 in the fibrotic cascade. Given the tissue-specific modulation of fibrosis, comprehending the molecular underpinnings of penile fibrosis becomes imperative for the innovation of novel and efficacious therapies targeting Peyronie’s disease. This review stands as a valuable resource for researchers and clinicians engaged in investigating the molecular basis of fibrotic diseases, offering guidance for advancements in understanding Peyronie’s disease.
Yazarlar (7)
1
Ali Şahin
ORCID: 0000-0002-3139-8205
2
Huseyn Babayev
ORCID: 0000-0001-6985-9436
3
Lorenzo Cirigliano
ORCID: 0000-0002-8732-4272
4
Mirko Preto
ORCID: 0000-0002-8144-6498
5
Marco Falcone
ORCID: 0000-0003-1101-892X
6
Emre Altıntaş
ORCID: 0000-0002-6797-3937
7
Murat Gul
ORCID: 0000-0002-6657-6227
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Università degli Studi di Torino
Turin Italy
Universität Zürich
Zurich Switzerland
Metrikler
1
Atıf
7
Yazar