Scopus
YÖKSİS DOI Eşleşti
SJR Q3
Evaluation of acute phase proteins, some cytokines and hemostatic parameters in dogs with sepsis
Kafkas Universitesi Veteriner Fakultesi Dergisi · Eylül 2015
YÖKSİS Kayıtları
Evaluation of Acute Phase Proteins Some Cytokines and Hemostatic Parameters in Dogs with Sepsis
Kafkas Universitesi Veteriner Fakultesi Dergisi · 2015 SCI-Expanded 2 atıf
Prof. Dr. HASAN GÜZELBEKTEŞ →
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Evaluation of Acute Phase Proteins Some Cytokines and Hemostatic Parameters in Dogs with Sepsis
2015 ISSN: 1300-6045 SCI-Expanded 2 atıf
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Evaluation of Acute Phase Proteins Some Cytokines and Hemostatic Parameters in Dogs with Sepsis
2015 ISSN: 1300-6045 SCI-Expanded 2 atıf
Prof. Dr. HASAN GÜZELBEKTEŞ →
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Makale Bilgileri
ISSN13006045
Yayın TarihiEylül 2015
Cilt / Sayfa21 · 761-766
Scopus ID2-s2.0-84934762382
Özet
The aim of this study was to evaluate the alterations in acute phase proteins, cytokines and hemostatic parameters in dogs with sepsis and to determine the importance of these parameters in diagnosis of the sepsis. Thirty dogs with sepsis and 9 healthy dogs were used in this study. Anorexia, depression, lethargy, hyperthermia, tachycardia, tachypnea, congestion in the mucosal membranes, prolonged capillary refill time, and leukocytosis or leucopenia were identified in the dogs with sepsis. The serum interleukin-1ß (IL-1ß), tumor necrosis factor α (TNF-α), interferon γ (INF-γ), C-reactive protein (CRP), serum amyloid A (SAA), prothrombin time (PT), activated partial thromboplastin time (aPTT), antithrombin III (AT III), fibrinogen, protein C (PC), and D-dimer levels were measured in all dogs. We found that the serum IL-1ß, TNF-α, INF-γ, CRP and SAA concentrations were significantly elevated in dogs with sepsis as compared with healthy controls. In addition, the plasma PT and APTT levels were notably prolonged, the plasma fibrinogen, D-dimers and protein C concentrations were significantly increased. However, the antithrombin III activity was significantly decreased in the dogs with sepsis. In conclusion, the results of this study indicate that the SAA, IL-1ß and TNF-α parameters play important roles in the inflammatory process in dogs with sepsis. The hemostatic abnormalities observed in dogs with sepsis may be due to the development of disseminated intravascular coagulation (DIC).
Yazarlar (7)
1
M. Ok
2
C. Er
3
Ramazan Yildiz
4
Ramazan Col
5
Ugur Aydogdu
6
Ismail Sen
7
Hasan Guzelbektes
ORCID: 0000-0002-0227-0691
Anahtar Kelimeler
Acute phase protein
Coagulation profile
Cytokines
Dogs
Sepsis
Kurumlar
Burdur Mehmet Akif Ersoy Üniversitesi
Burdur Turkey
Cumhuriyet Üniversitesi
Sivas Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Kafkas Universitesi Veteriner Fakultesi Dergisi
Q3
OA
SJR Skoru0,261
H-Index29
YayıncıKafkas University
ÜlkeTurkey
Veterinary (miscellaneous) (Q3)
Metrikler
13
Atıf
7
Yazar
5
Anahtar Kelime