Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
The changes in biomarkers for necrotising enterocolitis in premature calves with respiratory distress syndrome
Veterinarni Medicina · Ocak 2019
YÖKSİS Kayıtları
The changes in biomarkers for necrotising enterocolitis in premature calves with respiratory distress syndrome
Veterinární medicína · 2019 SCI-Expanded
DOÇENT AMİR NASERİ →
The changes in biomarkers for necrotising enterocolitis in premature calves with respiratory distress syndrome
Veterinární medicína · 2019 SCI-Expanded
DOÇENT MERVE İDER →
The changes in biomarkers for necrotising enterocolitis in premature calves with respiratory distress syndrome
Veterinární medicína · 2019 SCI-Expanded
PROFESÖR MAHMUT OK →
Makale Bilgileri
DergiVeterinarni Medicina
Yayın TarihiOcak 2019
Cilt / Sayfa64 · 440-447
Scopus ID2-s2.0-85075495097
Erişim🔓 Açık Erişim
Özet
The aim of this study was to determine the changes of the biomarkers used for the diagnosis of necrotising enterocolitis of human neonates in premature calves with respiratory distress syndrome (RDS). Novel biomarkers including the intestinal fatty acid binding protein (IFABP), the liver-type FABP (LFABP), trefoil factor-3 (TFF3), actin gamma 2 smooth muscle (ACTG2), and Claudin-3 were investigated using bovine specific ELISA kits. Thirty premature calves with respiratory distress syndrome (the RDS group), seven premature calves without RDS (the non-RDS group), and seven healthy calves (control) were included in the study. Blood samples from all the groups were taken at 0 and 48 h for the blood gas and biomarker measurement. It was determined that IFABP (P < 0.05), LFABP (P < 0.05), TFF3 (P < 0.05), ACTG2 (P < 0.05), and Claudin-3 (P < 0.05) in the control group were significantly higher than those in the RDS and non-RDS groups at 0 hour. The LFABP and Claudin-3 concentrations in the control group were statistically higher (P < 0.05) than those in the RDS and non-RDS groups at 48 h, whereas the ACTG2 and TFF3 contents were significantly higher (P < 0.05) than the non-RDS group. A significant increase in the contents of IFABP (P ≤ 0.01), LFABP (P < 0.05), TFF3 (P < 0.05), ACTG2 (P < 0.05) at 48 h was detected in the RDS group only. In conclusion, the changes in the biomarkers support the suspicion of intestinal damage such as necrotising enterocolitis (NEC) after enteral feeding in premature calves with RDS. Intestinal damage biomarkers such as IFABP, LFABP, TFF3, and ACTG2 may be useful in the diagnosis of intestinal damage in premature calves. These results also indicate that the plasma concentrations of the intestinal biomarkers change in new born calves with their gestational age.
Yazarlar (6)
1
Ramazan Yildiz
2
M. Ok
3
Merve Ider
ORCID: 0000-0003-2928-5452
4
A. Akar
5
Amir Naseri
6
Erman Koral
Anahtar Kelimeler
Actin
Claudin
FABP
Hypoxia
Trefoil factor
Kurumlar
Mehmet Akif University
Burdur Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
9
Atıf
6
Yazar
5
Anahtar Kelime