Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q3
Changes in novel gastrointestinal and renal injury markers in the blood plasma of sheep following increasing intravenous doses of tolfenamic acid
Acta Veterinaria Hungarica · Ocak 2019
YÖKSİS Kayıtları
CHANGES IN NOVEL GASTROINTESTINAL AND RENAL INJURY MARKERS IN THE BLOOD PLASMA OF SHEEP FOLLOWING INCREASING INTRAVENOUS DOSES OF TOLFENAMIC ACID
ACTA VETERINARIA HUNGARICA · 2019 SCI
Prof. Dr. KAMİL ÜNEY →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Zinc supplementation decreases total thyroid hormone concentration in small ruminants
2002 ISSN: 0236-6290 SCI 18 atıf
Prof. Dr. TUFAN KEÇECİ →
Effects of bovine viral diarrhoea virus on the fertility of cows
2013 ISSN: 0236-6290 SSCI
Prof. Dr. SİBEL YAVRU →
ASSESSMENT OF THE CARDIOTOXICITY OF TULATHROMYCIN IN RABBITS
2011 ISSN: 0236-6290 SCI-Expanded 37 atıf
Prof. Dr. MUAMMER ELMAS →
EFFECTS OF ENROFLOXACIN FLUNIXIN MEGLUMINE AND DEXAMETHASONE ONDISSEMINATED INTRAVASCULAR COAGULATION CYTOKINE LEVELS AND ADENOSINEDEAMINASE ACTIVITY IN ENDOTOXAEMIA IN RATS
2010 ISSN: 0236-6290 SCI-Expanded 23 atıf
Prof. Dr. MUAMMER ELMAS →
EFFECTS OF TYLOSIN ON SERUM CYTOKINE LEVELS IN HEALTHY ANDLIPOPOLYSACCHARIDE TREATED MICE
2010 ISSN: 0236-6290 SCI-Expanded 18 atıf
Prof. Dr. MUAMMER ELMAS →
Zinc Supplementation Decreases Total Thyroid Hormone Concentration in Small Ruminants
2002 ISSN: 0236-6290 SCI-Expanded
Prof. Dr. ERCAN KESKİN →
Cardiac biomarkers in premature calves with respiratory distress syndrome
2016 ISSN: 0236-6290 SCI
Prof. Dr. HASAN GÜZELBEKTEŞ →
Effects of bovine viral diarrhoea virus on the fertility of cows
2013 ISSN: 0236-6290 SCI-Expanded
Prof. Dr. ORHAN YAPICI →
Effect of pentoxifylline on endotoxin induced haemostatic disturbances in rabbits
2005 ISSN: 0236-6290 SCI 7 atıf
Prof. Dr. RAMAZAN ÇÖL →
Effect of recombinant interleukin 10 on some haematological and biochemical parameters in a rat endotoxaemic model
2011 ISSN: 0236-6290 SCI 6 atıf
Prof. Dr. RAMAZAN ÇÖL →
Effects of Arginine and Trehalose on Post-thawed Bovine Sperm Quality
2017 ISSN: 0236-6290 SCI
Prof. Dr. MUSTAFA NUMAN BUCAK →
Effects of arginine and trehalose on post-thawed bovine sperm quality
2017 ISSN: 0236-6290 SCI
Prof. Dr. NURİ BAŞPINAR →
Plasma disposition of cefoperazone after single intravenous and intramuscular administrations in camels (Camelus dromedarius) )/title
2018 ISSN: 0236-6290 SCI-Expanded
Prof. Dr. MUAMMER ELMAS →
title Plasma disposition of cefoperazone after single intravenous and intramuscular administrations in camels ( iCamelus dromedarius/i )/title
2018 ISSN: 0236-6290 SCI-Expanded
Prof. Dr. KAMİL ÜNEY →
Assessment of the cardiotoxicity of tulathromycin in rabbits
2011 ISSN: 0236-6290 SSCI
Prof. Dr. ENVER YAZAR →
Effect of pentoxifylline on endotoxin-induced haemostatic, disturbances in rabbits
2005 ISSN: 0236-6290 SCI-Expanded
Prof. Dr. ERCAN KESKİN →
Changes In Novel Gastrointestinal And Renal Injury Markers In The Blood Plasma Of Sheep Following Increasing Intravenous Doses Of Tolfenamic Acid
2019 ISSN: 0236-6290 SCI
Prof. Dr. MAHMUT OK →
Heart-type fatty acid-binding protein (H-FABP), pentraxin-3 (PTX-3) and thrombomodulin in bovine traumatic pericarditis
2019 ISSN: 0236-6290 SCI-Expanded Q3
Doç. Dr. MERVE İDER →
CHANGES IN NOVEL GASTROINTESTINAL AND RENAL INJURY MARKERS IN THE BLOOD PLASMA OF SHEEP FOLLOWING INCREASING INTRAVENOUS DOSES OF TOLFENAMIC ACID
2019 ISSN: 0236-6290 SCI
Prof. Dr. KAMİL ÜNEY →
Effects of tylosin, tilmicosin and tulathromycin on inflammatory mediators in bronchoalveolar lavage fluid of lipopolysaccharide-induced lung injury
2012 ISSN: 0236-6290 SCI-Expanded
Prof. Dr. ENVER YAZAR →
Makale Bilgileri
ISSN02366290
Yayın TarihiOcak 2019
Cilt / Sayfa67 · 87-97
Scopus ID2-s2.0-85064109871
Erişim🔓 Açık Erişim
Özet
The administration of high doses of non-steroidal anti-inflammatory drugs (NSAID), such as tolfenamic acid (TA), has undesirable effects on different organs. Some novel biomarkers have been reported that can determine the gastrointestinal and renal injury caused by a high dose of NSAIDs or other toxic substances. This study was aimed at determining the changes in gastrointestinal (TFF2 and HYP), renal (NGAL and KIM-1) and cardiac (cTn-I, CK-MB) injury markers after the use of increasing intravenous doses of TA in sheep. TA was administered intravenously to groups of six sheep each, at the dose levels of 0 (Group 0, i.e., G0), 2 (G2), 4 (G4), 8 (G8) and 16 (G16) mg/kg. The concentrations of the studied biomarkers were measured at 3, 9, 18 and 36 h after administration of TA. The TFF2 and NGAL concentrations in G16 were found to be significantly higher (P < 0.05) than in the other groups except for G8 at different sampling times. HYP concentration in G16 was observed to be significantly (P < 0.05) lower than that in all other groups at 36 h. KIM-1 level in G16 was significantly (P < 0.05) higher than in all other groups at different sampling times. An increase in the renal markers, KIM-1 and NGAL, in G8 was observed before any change in plasma creatinine and urea. The cardiac marker cTn-I in G16 was significantly (P < 0.05) higher than in other groups at different sampling times. The results showed that the novel biomarkers (HYP, TFF2, NGAL, and KIM-1) can be used to determine gastric and renal injury in sheep.
Yazarlar (7)
1
Ramazan Yildiz
2
Orhan Corum
ORCID: 0000-0003-3168-2510
3
O. Atik
4
D. Durna Corum
5
Feray Altan
6
M. Ok
7
Kamil Üney
ORCID: 0000-0002-8674-4873
Anahtar Kelimeler
Biomarkers
Cardiac
Gastrointestinal
Injury
Renal
Tolfenamic acid
Kurumlar
Afyon Kocatepe Üniversitesi
Afyonkarahisar Turkey
Burdur Mehmet Akif Ersoy Üniversitesi
Burdur Turkey
Kastamonu University
Kastamonu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Acta Veterinaria Hungarica
Q3
SJR Skoru0,281
H-Index42
YayıncıAkademiai Kiado ZRt.
ÜlkeHungary
Veterinary (miscellaneous) (Q3)
Metrikler
13
Atıf
7
Yazar
6
Anahtar Kelime