Scopus
YÖKSİS Eşleşti
Intravenous pharmacokinetics of moxifloxacin following simultaneous administration with flunixin meglumine or diclofenac in sheep
Journal of Veterinary Pharmacology and Therapeutics · Mart 2020
YÖKSİS Kayıtları
Intravenous pharmacokinetics of moxifloxacin following simultaneous administration with flunixin meglumine or diclofenac in sheep
Journal of Veterinary Pharmacology and Therapeutics · 2020 SCI-Expanded
PROFESÖR MAHMUT OK →
Intravenous pharmacokinetics of moxifloxacin following simultaneous administration with flunixin meglumine or diclofenac in sheep
Journal of Veterinary Pharmacology and Therapeutics · 2020 SCI-Expanded
DOÇENT MERVE İDER →
Intravenous pharmacokinetics of moxifloxacin following simultaneous administration with flunixin meglumine or diclofenac in sheep
Journal of Veterinary Pharmacology and Therapeutics · 2020 SCI-Expanded
PROFESÖR KAMİL ÜNEY →
Makale Bilgileri
DergiJournal of Veterinary Pharmacology and Therapeutics
Yayın TarihiMart 2020
Cilt / Sayfa43 · 108-114
Scopus ID2-s2.0-85079713561
Özet
In this study, the pharmacokinetics of moxifloxacin (5 mg/kg) was determined following a single intravenous administration of moxifloxacin alone and co-administration with diclofenac (2.5 mg/kg) or flunixin meglumine (2.2 mg/kg) in sheep. Six healthy Akkaraman sheep (2 ± 0.3 years and 53.5 ± 5 kg of body weight) were used. A longitudinal design with a 15-day washout period was used in three periods. In the first period, moxifloxacin was administered by an intravenous (IV) injection. In the second and third periods, moxifloxacin was co-administered with IV administration of diclofenac and flunixin meglumine, respectively. The plasma concentration of moxifloxacin was assayed by high-performance liquid chromatography. The pharmacokinetic parameters were calculated using a two-compartment open pharmacokinetic model. Following IV administration of moxifloxacin alone, the mean elimination half-life (t<inf>1/2β</inf>), total body clearance (Cl<inf>T</inf>), volume of distribution at steady state (V<inf>dss</inf>) and area under the curve (AUC) of moxifloxacin were 2.27 hr, 0.56 L h<sup>−1</sup> kg<sup>−1</sup>, 1.66 L/kg and 8.91 hr*µg/ml, respectively. While diclofenac and flunixin meglumine significantly increased the t<inf>1/2β</inf> and AUC of moxifloxacin, they significantly reduced the Cl<inf>T</inf> and V<inf>dss</inf>. These results suggest that anti-inflammatory drugs could increase the therapeutic efficacy of moxifloxacin by altering its pharmacokinetics.
Yazarlar (7)
1
Feray Altan
2
Orhan Corum
ORCID: 0000-0003-3168-2510
3
Ramazan Yildiz
4
H. Eser Faki
5
Merve Ider
ORCID: 0000-0003-2928-5452
6
M. Ok
7
Kamil Üney
ORCID: 0000-0002-8674-4873
Anahtar Kelimeler
diclofenac
flunixin meglumine
moxifloxacin
pharmacokinetics
sheep
Kurumlar
Burdur Mehmet Akif Ersoy Üniversitesi
Burdur Turkey
Dicle Üniversitesi
Diyarbakir Turkey
Kastamonu University
Kastamonu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
11
Atıf
7
Yazar
5
Anahtar Kelime