Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
1H-NMR Analysis of Amino Acid Metabolism in Cerebrospinal Fluid of Dogs with Neurological Distemper
Macedonian Veterinary Review · Ekim 2024
YÖKSİS Kayıtları
1H-NMR Analysis of Amino Acid Metabolism in Cerebrospinal Fluid of Dogs with Neurological Distemper
Macedonian Veterinary Review · 2024 CABİ
PROFESÖR MAHMUT OK →
Makale Bilgileri
DergiMacedonian Veterinary Review
Yayın TarihiEkim 2024
Cilt / Sayfa47 · 131-140
Scopus ID2-s2.0-85204901564
Erişim🔓 Açık Erişim
Özet
Canine Distemper Virus (CDV) infection causes a multifocal demyelinating progressive disease within the central nervous system (CNS) that results in wide range of neurological symptoms. Pathological changes in the brain or CNS could be observed by analyzing cerebrospinal fluid (CSF). Therefore, this study aimed to investigate the concentrations of amino acids in the CSF of dogs with neurological form of CDV infection, and to identify amino acids as markers that can be used in the diagnosis, pathogenesis, and treatment of the disease. Heathy dogs (n=6), confirmed by clinical and laboratory examinations (Healthy group), and CDV-infected dogs (n=10) with neurological symptoms, confirmed by clinical, laboratory, and rapid diagnostic test kits (Distemper group), were used. CSF samples were obtained with an appropriate method and were subjected to 1H-NMR analysis. Identification was made on 10, whereas quantification on 8 amino acids. L-tyrosine, L-phenylalanine, L-threonine, and L-alanine concentrations were significantly lower, while L-histidine and L-tryptophan were significantly higher than the Healthy group (p<0.05). It was concluded that L-tyrosine could be used for assessing mental status changes, L-phenylalanine for evaluating neuroprotective responses, L-threonine and L-histidine for gauging the extent of neurodegeneration and ventricular degeneration, L-alanine for exploring cellular stress and energy metabolism, and L-tryptophan for understanding the process of sympathetic nervous system activation.
Yazarlar (7)
1
Erdem Gülersoy
ORCID: 0000-0001-8511-0150
2
Canberk Balikçi
3
Ismail Günal
4
Adem Şahan
5
Esma Kismet
6
Fatma Akdaǧ
7
M. Ok
Anahtar Kelimeler
amino acid
biomarker
CSF
dogs
NMR
Kurumlar
Harran Üniversitesi
Sanliurfa Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
1
Atıf
7
Yazar
5
Anahtar Kelime