Scopus
YÖKSİS Eşleşti
How should procalcitonin and C-reactive protein levels be interpreted in haemodialysis patients?
Internal Medicine Journal · Ekim 2018
YÖKSİS Kayıtları
How should procalcitonin and C-reactive protein levels be interpreted in haemodialysis patients?.
INTERNAL MEDICINE · 2018 SCI
PROFESÖR ŞUA SÜMER →
How should procalcitonin and C-reactive protein levels be interpreted in haemodialysis patients?
INTERNAL MEDICINE JOURNAL · 2018 SCI
PROFESÖR NAZLIM AKTUĞ DEMİR →
How should procalcitonin and C-reactive protein levels be interpreted in haemodialysis patients?
INTERNAL MEDICINE JOURNAL · 2018 SCI
PROFESÖR ONUR URAL →
How should procalcitonin and C-reactive protein levels be interpreted in haemodialysis patients?
Internal Medicine Journal · 2018 SCI
PROFESÖR ONUR URAL →
How should procalcitonin and C-reactive protein levels be interpreted in haemodialysis patients?
INTERNAL MEDICINE JOURNAL · 2018 SCI
PROFESÖR GÜLPERİ ÇELİK →
Makale Bilgileri
DergiInternal Medicine Journal
Yayın TarihiEkim 2018
Cilt / Sayfa48 · 1222-1228
Scopus ID2-s2.0-85054338529
Özet
Background: Procalcitonin (PCT) and C-reactive protein (CRP) are used most widely in the diagnosis/treatment of bacterial infections. These are not infection-specific and may also show increases in other inflammation-causing cases. Aim: To establish a new cut-off value for PCT and CRP to eliminate confusion in the diagnosis and treatment of bacterial infections in haemodialysis (HD) patients. Methods: A total of 1110 patients, 802 with undocumented infection and 308 with documented infection, was included in the study. Results: A total of 802 patients with undocumented infection had a mean CRP value of 12.2 ± 9.6 mg/dL and a mean PCT value of 0.51 ± 0.96 ng/mL and the 308 patients with documented infection had a mean CRP value of 125.9 ± 83.3 mg/dL and a mean PCT value of 13.9 ± 26.9 ng/mL at the time of admittance. In HD patients, the cut-off values for CRP was determined as 19.15 mg/dL and for PCT as 0.685 ng/mL in the presence of infection. The use of these two parameters in combination (CRP ≥19.15 mg/dL and PCT ≥ 0.685 ng/mL) was found to have 95% positive predictive value (PPV) and 93% negative predictive value (NPV) for the diagnosis of infectious diseases in HD patients. When CRP ≥100 mg/dL and PCT ≥5 ng/mL, this was found to have 100% PPV and 94% NPV for the diagnosis of sepsis in HD patients. Conclusion: We specified PCT and CRP cut-off values with high PPV and NPV for revealing the presence of bacterial infection and sepsis in HD patients.
Yazarlar (6)
1
Nazlım Aktuğ Demir
2
Şua Sümer
3
Gülperi Çelik
4
Rengin E. Afsar
5
Lütfi Saltuk Demir
6
Onur Ural
Anahtar Kelimeler
chronic renal failure
C-reactive protein
haemodialysis
infection
procalcitonin
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Tip Fakültesi
Konya Turkey
Süleyman Demirel University, Faculty of Medicine
Isparta Turkey
Metrikler
15
Atıf
6
Yazar
5
Anahtar Kelime