Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q4
Protective Effect of Silymarin and Mitoquinone (MitoQ) Aganist Hepatotoxicity of Cadmium Telluride Quantum Dot (CdTe QDs) Nanoparticles in Mice
Revista Cientifica De La Facultad De Veterinaria · Ocak 2024
YÖKSİS Kayıtları
Protective Effect of Silymarin and Mitoquinone (MitoQ) Aganist Hepatotoxicity of Cadmium Telluride Quantum Dot (CdTe QDs) Nanoparticles in Mice
Revista Científica de la Facultad de Ciencias Veterinarias · 2024 SCI-Expanded
Arş. Gör. SEDA ŞİMŞEK →
Protective Effect of Silymarin and Mitoquinone (MitoQ) Aganist Hepatotoxicity of Cadmium Telluride Quantum Dot (CdTe QDs) Nanoparticles in Mice
Revista Científica de la Facultad de Ciencias Veterinarias · 2024 SCI-Expanded
Dr. Öğr. Üyesi NEJAT ÜNLÜKAL →
Protective Effect of Silymarin and Mitoquinone (MitoQ) Aganist Hepatotoxicity of Cadmium Telluride Quantum Dot (CdTe QDs) Nanoparticles in Mice
Revista Científica de la Facultad de Ciencias Veterinarias · 2024 SCI-Expanded
Dr. Öğr. Üyesi MUSLU KAZIM KÖREZ →
Protective Effect of Silymarin and Mitoquinone (MitoQ) Aganist Hepatotoxicity of Cadmium Telluride Quantum Dot (CdTe QDs) Nanoparticles in Mice
Revista Científica de la Facultad de Ciencias Veterinarias · 2024 SCI-Expanded
Prof. Dr. ENDER ERDOĞAN →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Effect of Tarantula cubensis alcoholic extract and Nerium oleander distillate on cell proliferation markers in colon carcinogenesis
2022 ISSN: 0798-2259 SCI-Expanded Q4
Prof. Dr. ÖZGÜR ÖZDEMİR →
Effect of Tarantula cubensis alcoholic extract and Nerium oleander distillate on cell proliferation markers in colon carcinogenesis
2022 ISSN: 0798-2259 SCI-Expanded
Prof. Dr. MEHMET TUZCU →
Investigation with Real-Time PCR and Histopathology on the presence of H. felis, H. heilmannii and H. pylori in dogs
2023 ISSN: 0798-2259 SCI-Expanded Q4
Arş. Gör. ZEYNEP ÇELİK KENAR →
Investigation with Real-Time PCR and Histopathology on the presence of H. felis, H. heilmannii and H. pylori in dogs
2023 ISSN: 0798-2259 SCI-Expanded
Doç. Dr. NEVİN TUZCU →
Determination of Embryotoxic effects of Atipamezole using in ovo model
2023 ISSN: 0798-2259 SCI-Expanded Q4
Dr. Öğr. Üyesi HARUN KIZILAY →
Evaluation of tumor necrosis Factor Alpha, Interferon Gamma, Procalcitonin and Neopterin levels in Brucella seropositive cattle
2023 ISSN: 0798-2259 SCI-Expanded
Doç. Dr. NEVİN TUZCU →
ELISA-based Point Prevalence of enteropathogens in diarrheic calves in Central Anatolia Region of Turkey
2023 ISSN: 0798-2259 SCI-Expanded Q4
Prof. Dr. ÖZLEM DERİNBAY EKİCİ →
Effect of Tarantula cubensis alcohol extract and Capecitabin combine in Colorectal Cancer rats
2023 ISSN: 0798-2259 Google scholar, sci, EBSCO, SCİ ELO, DOAJ, Latindex
Prof. Dr. AHMET LEVENT BAŞ →
Determination of the embryotoxic effect of Metronidazole using an in ovo model
2024 ISSN: 0798-2259 SCI-Expanded Q4
Dr. Öğr. Üyesi HARUN KIZILAY →
ELISA–based Point Prevalence of enteropathogens in diarrheic calves in Central Anatolia Region of Turkey
2023 ISSN: 0798-2259 CABI
Prof. Dr. OĞUZHAN AVCI →
ELISA-based Point Prevalence of enteropathogens in diarrheic calves in Central Anatolia Region of Turkey
2023 ISSN: 0798-2259 SCI-Expanded Q4
Prof. Dr. NERMİN IŞIK USLU →
Effect of Tarantula cubensis alcohol extract and Capecitabin combine in Colorectal Cancer rats
2023 ISSN: 0798-2259 SCI-Expanded Q4
Prof. Dr. AHMET LEVENT BAŞ →
Microbiological characterization and genetic analysis of bacteria isolated from blood cultures and fecal samples in calves with symptoms of septicemia and diarrhea
2023 ISSN: 0798-2259 SCI-Expanded Q4
Prof. Dr. ZAFER SAYIN →
Microbiological characterization and genetic analysis of bacteria isolated from blood cultures and fecal samples in calves with symptoms of septicemia and diarrhea
2024 ISSN: 0798-2259 SCI-Expanded Q4
Doç. Dr. ASLI BALEVİ →
Morphometric investigation of the effects of Azoxymethane, Diallyl disulfide and corn oil use on humerus and femur development in rats
2024 ISSN: 0798-2259 SCI-Expanded Q4
Dr. Öğr. Üyesi SEDAT AYDOĞDU →
Microbiological characterization and genetic analysis of bacteria isolated from blood cultures and fecal samples in calves with symptoms of septicemia and diarrhea
2024 ISSN: 0798-2259 SCI-Expanded Q4
Doç. Dr. ALİ USLU →
Protective Effect of Silymarin and Mitoquinone (MitoQ) Aganist Hepatotoxicity of Cadmium Telluride Quantum Dot (CdTe QDs) Nanoparticles in Mice
2024 ISSN: 0798-2259 SCI-Expanded Q4
Prof. Dr. ENDER ERDOĞAN →
Protective Effect of Silymarin and Mitoquinone (MitoQ) Aganist Hepatotoxicity of Cadmium Telluride Quantum Dot (CdTe QDs) Nanoparticles in Mice
2024 ISSN: 0798-2259 SCI-Expanded Q4
Dr. Öğr. Üyesi MUSLU KAZIM KÖREZ →
Pathological and biochemical investigation of the effects of Silybum marianum against Methomyl damage in broiler liver
2024 ISSN: 0798-2259 SCI-Expanded
Prof. Dr. ERTAN ORUÇ →
Effect of propolis on pyruvate kinase and superoxide dismutase activities in doxorubicin–induced tissue damage: Molecular docking analysis
2024 ISSN: 0798-2259 SCI-Expanded Q4
Dr. Öğr. Üyesi HARUN YONAR →
Makale Bilgileri
ISSN07982259
Yayın TarihiOcak 2024
Cilt / SayfaXXXIV
Scopus ID2-s2.0-85214371385
Erişim🔓 Açık Erişim
Özet
As a result of the increasing use of quantum dots (QDs) and increased exposure of human beings to quantum dots, the study of the toxicity of the particles has become an important issue. In this study, the protective activity of silymarin and mitoquinone (MitoQ), which are known to have antioxidant properties, on the histopathological and biochemical changes observed in the liver of mice treated with CdTe QDs was investigated. 26 male Swiss mice were randomly divided into four groups: Control (G1), CdTe QDs (G2), silymarin + CdTe QDs (G3), mitoquinone + CdTe QDs (G4) application groups. Animals were sacrificed 24 hours (h) after injections and hyperspectral microscopy images were obtained. According to the ICP–MS results, the CdTe QDs injected through the tail vein accumulated in the liver at the end of 24 h and caused tissue damage according to the hematoxylin & eosin examination, and better preservation was observed with the antioxidant pre–treatment. The immunofluorescence results showed increased inflammation and apoptosis in the QDs group. It was observed that silymarin and mitoquinone decreased anti–MMP–9, anti–IL–10, anti–IL–1b, anti–TNF–α, and anti–caspase–9, TUNEL– positive cell ratio, liver MDA levels. There was no significant difference in serum TAS (P=0.509), TOS (P=0.588) levels, but antioxidants also increased tissue SOD and CAT levels. Antioxidants had no significant effect on anti–MT–MMP2 and anti–caspase–8 levels (P<0.001). In conclusion, it was shown that pretreatment of CdTe QD–administered mice with silymarin and mitoquinone can reduce oxidative stress in liver tissue and may have a protective effect through reduction of apoptosis and inflammation.
Yazarlar (6)
1
S. Şimsek
2
Merve Solmaz
3
İsmail Hakkı Nur
ORCID: 0000-0001-7215-8112
4
M. K. Korez
ORCID: 0000-0001-9524-6115
5
Nejat Ünlükal
ORCID: 0000-0002-8107-4882
6
Ender Erdoğan
Anahtar Kelimeler
Antioxidant
mitoquinone
oxidative stress
quantum dot
silymarin
Kurumlar
Erciyes Üniversitesi
Kayseri Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Revista Cientifica de la Facultad de Veterinaria
Q4
OA
SJR Skoru0,138
H-Index16
YayıncıUniversidad del Zulia, Facultad de Ciencias Veterinarias
ÜlkeVenezuela
Animal Science and Zoology (Q4)
Food Science (Q4)
Immunology and Microbiology (miscellaneous) (Q4)
Veterinary (miscellaneous) (Q4)
Metrikler
1
Atıf
6
Yazar
5
Anahtar Kelime