Scopus
YÖKSİS Eşleşti
Evaluation of serum interleukin-6 (IL-6), IL-13, and IL-17 levels and computed tomography finding in interstitial lung disease associated with connective tissue disease patients
Clinical Rheumatology · Kasım 2021
YÖKSİS Kayıtları
Evaluation of serum interleukin-6 (IL-6), IL-13, and IL-17 levels and computed tomography finding in interstitial lung disease associated with connective tissue disease patients
Clinical Rheumatology · 2021 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ MUSLU KAZIM KÖREZ →
Evaluation of serum interleukin-6 (IL-6), IL-13, and IL-17 levels and computed tomography finding in interstitial lung disease associated with connective tissue disease patients
Clinical Rheumatology · 2021 SCI-Expanded
DOÇENT HALİL ÖZER →
Evaluation of Serum Interleukin-6 (IL-6), IL-13 and IL-17 Levels and Computed Tomography Finding in Interstitial Lung Disease Associated with Cönnective Tissue Disease Patients
Clinical Rheumatology · 2021 SCI-Expanded
PROFESÖR SEMA YILMAZ →
Evaluation of serum interleukin-6 (IL-6), IL-13, and IL-17 levels and computed tomography finding in interstitial lung disease associated with connective tissue disease patients
Springer Science and Business Media LLC · 2021 SCI-Expanded
DOÇENT DİLEK ERGÜN →
Evaluation of serum interleukin-6 (IL-6), IL-13, and IL-17 levels and computed tomography finding in interstitial lung disease associated with connective tissue disease patients
Clinical Rheumatology · 2021 SCI-Expanded
PROFESÖR ABDULLAH SİVRİKAYA →
Makale Bilgileri
DergiClinical Rheumatology
Yayın TarihiKasım 2021
Cilt / Sayfa40 · 4713-4724
Scopus ID2-s2.0-85117207081
Özet
Objective: Interstitial lung disease (ILD) is one of the most severe complications which is associated with connective tissue disease (CTD) and causes to morbidity and mortality. So, we aimed to determine serum levels of interleukin-6 (IL-6), IL-13, and IL-17, to investigate whether these cytokines are related to CTD-ILD, and to find their possible contribution to determining the prognosis of the disease. Methods: A total of 150 participants, 80 patients diagnosed with CTD-ILD (mean age, 58.21 ± 12.36) and 70 healthy controls (mean age, 57.07 ± 9.60) were recruited from the rheumatology department between January 2016 and June 2019 in the study. High-resolution computed tomography (HRCT) findings were scored as similarly to previous studies. Serum IL-6, IL 13, and IL-17 levels were measured by ELISA test kits. Results: The levels of IL-6, IL-13, and IL-17 in CTD patients were significantly higher than the healthy individuals (p < 001), but the HRCT score’s relation were not determined. IL-6 was associated with disease duration and disease activity scores of DAS28, ESDAII, and dSSc. There was a significant relation between dSSc, HCRT fibrosis, and total score.CRP, hemoglobin, and platelets were associated with the HRCT inflammation pattern. Conclusion: At the study, it has been observed that serum IL-13, IL-6 and IL-17 levels are increased in patients with CTD-ILD. Besides, IL-6 was associated with disease activity scores of DAS28, ESDAII, and dSSc. Also, HRCT fibrosis score is associated with dSSc. Further and comprehensive studies are needed to understand better the complex intersection of lung disease with systemic autoimmunity.Key Points•Serum IL-13, IL-6, and IL-17 levels are increased in patients with CTD-ILD.•IL-6 was associated with disease activity scores of DAS28, ESDAII, and diffuse skin involvement.•HRCT fibrosis score is associated with diffuse skin involvement in patients with SSc-ILD.•HRCT inflammation score is associated with PAH.
Yazarlar (10)
1
Dilek Tezcan
ORCID: 0000-0002-8295-9770
2
Abdullah Sivrikaya
3
Dilek Ergün
4
Halil Özer
ORCID: 0000-0003-1141-1094
5
Duygu Eryavuz Onmaz
ORCID: 0000-0001-8564-1824
6
M. K. Korez
ORCID: 0000-0001-9524-6115
7
Turan Akdağ
ORCID: 0000-0003-3175-6751
8
Semral Gülcemal
ORCID: 0000-0002-6085-9939
9
Muhammet Limon
ORCID: 0000-0002-5693-7885
10
Sema Yılmaz
ORCID: 0000-0003-4277-3880
Anahtar Kelimeler
Connective tissue disease
Interleukin-13
Interleukin-17
Interleukin-6
Interstitial lung diseases
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
11
Atıf
10
Yazar
5
Anahtar Kelime