Scopus
YÖKSİS Eşleşti
Nicotinamide N-methyltransferase expression in squamous cell carcinoma of the vulva
Journal of Obstetrics and Gynaecology · Ocak 2022
YÖKSİS Kayıtları
Nicotinamide N-methyltransferase expression in squamous cell carcinoma of the vulva
Informa UK Limited · 2022 SCI-Expanded
PROFESÖR ÇETİN ÇELİK →
Nicotinamide N-methyltransferase expression in squamous cell carcinoma of the vulva
JOURNAL OF OBSTETRICS AND GYNAECOLOGY · 2022 SCI
PROFESÖR ZELİHA ESİN ÇELİK →
Nicotinamide N-methyltransferase expression in squamous cell carcinoma of the vulva
JOURNAL OF OBSTETRICS AND GYNAECOLOGY · 2022 SCI-Expanded
PROFESÖR ZELİHA ESİN ÇELİK →
Makale Bilgileri
DergiJournal of Obstetrics and Gynaecology
Yayın TarihiOcak 2022
Cilt / Sayfa42 · 2325-2330
Scopus ID2-s2.0-85132662912
Özet
The molecular pathways involved in the development of vulvar squamous cell carcinoma (SCC) cancer are not completely known. Nicotinamide N-methyltransferase (NNMT) is a cytosolic enzyme associated with tumorigenesis and metastasis in a variety of cancers. Its role in vulvar cancer has not been studied, previously. Vulvar SCC, high and low grade squamous intraepithelial lesions (SILs) and benign squamous hyperplasia were analysed immunohistochemically. The mean staining score for vulvar SCC was significantly higher than the score for vulvar squamous hyperplasia (p<.001). The mean relapse-free survival for patients with low and high NNMT expression was 41.4 months (95% CI: 25.6–57.2) and 19.8 months (95% CI: 3.0–36.6), respectively (p=.035). The mean disease-specific survival for patients with low and high NNMT expression was 75.8 months (95% CI: 57.5–94.2) and 27.8 months (95% CI 12.2–43.4), respectively (p=.015). Although quite preliminary, this study showed that NNMT expression was elevated in vulvar SCC compared to benign and premalignant lesions. Additionally, elevated NNMT expression was associated with poor survival. Impact StatementWhat is already known on this subject? Nicotinamide N-methyltransferase (NNMT) is a methyltransferase, associated with tumour progression, spread and poor prognosis in a variety of cancers. Its upregulation can lead to DNA hypomethylation, which can in turn result in the activation of proto-oncogenes and deactivation of tumour suppressor genes. What do the results of this study add? Although quite preliminary, this study showed that NNMT expression was elevated in vulvar SCC compared to benign and premalignant lesions. Additionally, elevated NNMT expression was associated with poor survival. What are the implications of these findings for clinical practice and/or further research? NNMT has been regarded as a potential target of cancer therapy and its role in vulvar cancer has not been studied, previously. This is the first study to investigate the expression of NNMT in vulvar cancer and associate NNMT elevation with poor survival. NNMT can further be investigated as a possible target of vulvar cancer therapy.
Yazarlar (5)
1
Zeliha Esin Celik
2
Serra Akar
ORCID: 0000-0002-0466-140X
3
Sıdıka Fındık
ORCID: 0000-0002-3364-7498
4
Emine Aytekin
5
Çetin Çelik
ORCID: 0000-0001-6165-5092
Anahtar Kelimeler
Nicotinamide N-methyltransferase
squamous cell carcinoma
vulvar cancer
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey