Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q3
NNMT overexpression is an adverse prognostic factor in uterine leiomyosarcoma
Turkish Journal of Medical Sciences · Ocak 2024
YÖKSİS Kayıtları
NNMT overexpression is an adverse prognostic factor in uterine leiomyosarcoma
TURKISH JOURNAL OF MEDICAL SCIENCES · 2024 SCI-Expanded
Prof. Dr. ZELİHA ESİN ÇELİK →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Evaluation of 48 week response of treatment naive chronic hepatitis B patients to 0 5 mg day entecavir
2014 ISSN: 1300-0144 SCI-Expanded
Prof. Dr. ŞUA SÜMER →
Serum Interleukin 8 Levels May Predict Relapse In Brucellosis
2012 ISSN: 1300-0144 SCI-Expanded
Prof. Dr. NAZLIM AKTUĞ DEMİR →
Evaluation of 48 week Response of Treatment Naive Chronic Hepatitis B Patients to 0 5 mg day Entecavir
2014 ISSN: 1300-0144 SCI-Expanded
Prof. Dr. NAZLIM AKTUĞ DEMİR →
Pregnancy associated plasma protein A and procalcitonin as markers of myocardial injury in patients with acute coronary syndrome
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. BAHADIR ÖZTÜRK →
The efficacy of intermittant low dose systemic corticosteroid in the treatment of alopecia areata
2004 ISSN: 1300-0144 SCI-Expanded 1 atıf
Prof. Dr. GÜLCAN SAYLAM KURTİPEK →
Pregnancy associated plasma protein A and procalcitonin as markers of myocardial injury in patients with acute coronary syndrome
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. HASAN KARA →
Analysis of periprocedural medical complications during carotid angioplasty and stent placement
2010 ISSN: 1300-0144 SCI-Expanded
Prof. Dr. İBRAHİM ÖZKAN ÖNAL →
High risk febrile neutropenia and its management in childrenwith solid tumors and lymphoma
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. YAVUZ KÖKSAL →
Effects of grape seed extract on oxidative stress and antioxidant defensemarkers in streptozotocin induced diabetic rats
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. MUAZ BELVİRANLI →
Effectiveness of pelvic floor muscle training on symptoms and uroflowmetryparameters in female patients with overactive bladder
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. EVRİM ÇAKMAKÇI →
Effects of grape seed extract on oxidative stress and antioxidant defensemarkers in streptozotocin induced diabetic rats
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. NİLSEL OKUDAN →
Pregnancy associated plasma protein A and procalcitonin as markers of myocardial injury in patients with acute coronary syndrome
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. ABDULLAH SİVRİKAYA →
Refeeding hypophosphatemia a potentially fatal danger in the intensive care unit
2014 ISSN: 13000144 SCI-Expanded
Prof. Dr. SÜLEYMAN BALDANE →
Comparison of the efficacy of prednisolone montelukast and omalizumab in an experimental allergic rhinitis model
2014 ISSN: 1300-0144 SCI-Expanded
Prof. Dr. BANU BOZKURT →
Pregnancy associated plasma protein A and procalcitonin as markers of myocardial injury in patients with acute coronary syndrome
2015 ISSN: 13000144 SCI-Expanded
Prof. Dr. AYŞEGÜL BAYIR →
Comparison of the efficacy of prednisolone montelukast and omalizumab in an experimental allergic rhinitis model
2014 ISSN: 13000144 SCI-Expanded
Prof. Dr. METE KAAN BOZKURT →
Hypo and hypervolemic edema in children with steroid sensitive nephrotic syndrome
2015 ISSN: 13000144 SCI-Expanded Q3
Dr. Öğr. Üyesi MEHMET AKİF BÜYÜKAVCI →
Evaluation of dental technician’s pneumoconiosis using chest X-rayand HRCT: correlation between radiological and functional findings
2017 ISSN: 13000144 SCI-Expanded
Prof. Dr. RECAİ ERGÜN →
Cytokeratin 18 and h FABP levels in intestinal ischemia reperfusioninjury role of coenzyme Q10
2013 ISSN: 1300-0144 SSCI 2 atıf
Prof. Dr. NİLSEL OKUDAN →
N terminal pro brain natriuretic peptide levels in children with allergic rhinitis
2016 ISSN: 1300-0144 SCI-Expanded
Prof. Dr. HÜSAMETTİN VATANSEV →
Makale Bilgileri
ISSN13000144
Yayın TarihiOcak 2024
Cilt / Sayfa54 · 804-810
Scopus ID2-s2.0-85203679477
Erişim🔓 Açık Erişim
Özet
Background/aim: Uterine leiomyosarcomas (uLMS) are extremely rare high-grade tumors with a poor prognosis. Their etiopathogenesis remains largely unknown. The uterus is the most frequent site for LMS. uLMS and uterine leiomyoma (uLM) must frequently be differentiated in patients with a uterine mass. Nicotinamide N-methyltransferase (NNMT), a cytoplasmic protein, is involved in the progression and spread of a variety of cancer types. The expression of NNMT in a mesenchymal malignancy was not examined previously. This study represents the first investigation into NNMT expression in uLMS, uLM and benign uterine myometrium and correlates NNMT overexpression with worse prognosis in uLMS. Materials and methods: The expression of NNMT was investigated by immunohistochemistry on formalin-fixed paraffin-embedded tissue of uLMS in 31 patients, uLM in seven patients and benign myometrial in 31 patients. Results: The expression of NNMT in uLMS was markedly higher than in uLM and normal myometrial tissue (p < 0.001). The expression of NNMT in early stage uLMS was lower than in advanced stage disease (p = 0.034). NNMT expression was an independent prognostic factor in predicting recurrence-free survival in uLMS (p = 0.037). Conclusion: NNMT can aid in the preoperative differentiation of uLMS and uLM. The consequences of NNMT overexpression, such as the activation and inactivation of oncoproteins and tumor suppressor proteins, respectively, as well as the enrichment of the cancer stem cell population, overlap with the major mechanisms responsible for poor prognosis in mesenchymal tumors. NNMT may be investigated further in the context of antitumor treatment in patients with mesenchymal malignancies.
Yazarlar (5)
1
Osman Türkmen
ORCID: 0000-0002-1470-7731
2
Kamil Hakan Müftüoğlu
ORCID: 0000-0003-4069-0002
3
Nazmiye Dinçer
ORCID: 0000-0001-6478-7808
4
Zeliha Esin Celik
5
Serra Akar
ORCID: 0000-0002-0466-140X
Anahtar Kelimeler
leiomyoma
leiomyosarcoma
metastasis
Nicotinamide N-methyltransferase
survival
Kurumlar
Ankara Bilkent City Hospital
Ankara Turkey
Ankara Yildirim Beyazit University
Ankara Turkey
Selçuk Tip Fakültesi
Konya Turkey
University of Health Sciences
Istanbul Turkey
Scimago Dergi (ISSN Eşleşmesi)
Turkish Journal of Medical Sciences
Q3
SJR Skoru0,386
H-Index44
YayıncıTUBITAK
ÜlkeTurkey
Medicine (miscellaneous) (Q3)