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Investigation of Plasma TMAO Levels in Children and Adolescents with ADHD: A Cross-Sectional Study

Genel Tip Dergisi · Haziran 2025

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YÖKSİS Kayıtları
Investigation of Plasma TMAO Levels in Children and Adolescents with ADHD: A Cross-Sectional Study
Genel Tıp Dergisi · 2025 TR DİZİN
DOKTOR ÖĞRETİM ÜYESİ MUSTAFA ESAD TEZCAN →

Makale Bilgileri

DergiGenel Tip Dergisi
Yayın TarihiHaziran 2025
Cilt / Sayfa35 · 435-441
DOI10.54005/geneltip.1592267
Scopus ID2-s2.0-105010097595
Özet Introduction: Attention Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder in children and adolescents. Recent research has suggested a potential link between gut microbiota-derived metabolites, such as Trimethylamine N-oxide (TMAO), and neuropsychiatric disorders. This study aims to investigate plasma TMAO levels in children and adolescents with ADHD and explore the relationship between TMAO levels and the severity of ADHD symptoms. Methods: This cross-sectional study included 96 participants aged 7 to 15 years, consisting of 50 patients diagnosed with ADHD and 46 healthy controls. Plasma TMAO levels were measured using the Enzyme-Linked Immunosorbent Assay (ELISA) method. ADHD symptom severity was assessed using the T-DSM-IV-TR scale. Results: Plasma TMAO levels were significantly higher in the ADHD group compared to the control group (p=0.02). Additionally, a positive correlation was found between TMAO levels and the total T-DSM-IV-TR scores (p<0.001), indicating that higher TMAO levels are associated with more severe ADHD symptoms. No significant correlations were observed between TMAO levels and other subscale scores. Conclusion: The findings suggest that elevated plasma TMAO levels in children and adolescents with ADHD may be indicative of the disorder’s biochemical characteristics. Furthermore, TMAO could be linked to the severity of ADHD symptoms, highlighting its potential role in the pathophysiology of ADHD.

Yazarlar (4)

1
Ahmet Güleç
ORCID: 0000-0001-9979-5891
2
Serhat Türkoğlu
3
Ramazan Kocabaş
4
Mustafa Esat Tezcan
ORCID: 0000-0001-8362-1934

Anahtar Kelimeler

ADHD child and adolescent psychiatry gut microbiome neurotoxicity Trimethylamine N-oxide

Kurumlar

Selçuk Üniversitesi
Selçuklu Turkey

Sistemimizdeki Yazarlar

MT
MUSTAFA ESAD TEZCAN
DOKTOR ÖĞRETİM ÜYESİ

Hızlı Erişim

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