Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
The effects of metyrosine on ischemia-reperfusion-induced oxidative ovarian injury in rats: Biochemical and histopathological assessment
Anais Da Academia Brasileira De Ciencias · Ocak 2023
YÖKSİS Kayıtları
The effects of metyrosine on ischemia-reperfusion-induced oxidative ovarian injury in rats: Biochemical and histopathological assessment
An Acad Bras Cienc · 2023 SCI-Expanded
PROFESÖR NİHAL ÇETİN →
Makale Bilgileri
DergiAnais Da Academia Brasileira De Ciencias
Yayın TarihiOcak 2023
Cilt / Sayfa95
Scopus ID2-s2.0-85151469251
Erişim🔓 Açık Erişim
Özet
The aim of this study is to investigate the effect of metyrosine on ischemia-reperfusion (I/R) induced ovarian injury in rats in terms of biochemistry and histopathology. Rats were divided into: ovarian I/R (OIR), ovarian I/R+50 mg/kg metyrosine (OIRM) and sham (SG) operations. OIRM group received 50 mg/kg metyrosine one hour before the application of the anesthetic agent, OIR and SG group rats received equal amount of distilled water to be used as a solvent orally through cannula. Following the application of the anesthetic agent, ovaries of OIRM and OIR group rats were subjected to ischemia and reperfusion, each of which took two hours. This biochemical experiment findings revealed high levels of malondialdehyde (MDA) and cyclo-oxygenase-2 (COX-2) and low levels of total glutathione (tGSH), superoxide dismutase (SOD) and cyclo-oxygenase-1 (COX-1) in the ovarian tissue of OIR group, with significant histopathological injury. In metyrosine group, MDA and COX-2 levels were lower than the OIR group whereas tGSH, SOD and COX-1 levels were higher, with slighter histopathological injury. Our experimental findings indicate that metyrosine inhibits oxidative and pro-inflammatory damage associated with ovarian I/R in rats. These findings suggest that metyrosine could be useful in the treatment of ovarian injury associated with I/R.
Yazarlar (8)
1
Omer E. Yapca
ORCID: 0000-0002-5578-0126
2
Gulsah Aynaoglu Yildiz
ORCID: 0000-0002-3283-7783
3
Renad Mammadov
ORCID: 0000-0002-5785-1960
4
Nezahat Kurt
ORCID: 0000-0002-1685-5332
5
Betul Gundogdu
ORCID: 0000-0002-3786-3286
6
Yusuf K. Arslan
ORCID: 0000-0003-1308-8569
7
Halis Suleyman
ORCID: 0000-0002-9239-4099
8
Nihal Cetin
Anahtar Kelimeler
cyclo-oxygenase enzyme
ischemia-reperfusion
metyrosine
ovarian tissues
rat
Kurumlar
Ataturk University, Faculty of Medicine
Erzurum Turkey
Erzincan Binali Yıldırım Üniversitesi
Erzincan Turkey
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
2
Atıf
8
Yazar
5
Anahtar Kelime