Scopus
YÖKSİS Eşleşti
Fertility preservation in boys facing gonadotoxic cancer therapy
Nature Reviews Urology · Şubat 2022
YÖKSİS Kayıtları
Fertility preservation in boys facing gonadotoxic cancer therapy
Nature Reviews Urology · 2021 SSCI
DOÇENT MURAT GÜL →
Makale Bilgileri
DergiNature Reviews Urology
Yayın TarihiŞubat 2022
Cilt / Sayfa19 · 71-83
Scopus ID2-s2.0-85117267548
Özet
Patient survival following childhood cancer has increased with contemporary radiation and chemotherapy techniques. However, gonadotoxicity associated with treatments means that infertility is a common consequence in survivors. Novel fertility preservation options are emerging, but knowledge about these options amongst urologists and other medical professionals is lacking. Pre-pubertal boys generally do not produce haploid germ cells. Thus, strategies for fertility preservation require cryopreservation of tissue containing spermatogonial stem cells (SSCs). Few centres worldwide routinely offer this option and fertility restoration (including testicular tissue engraftment, autotransplantation of SSCs and in vitro maturation of SSCs to spermatozoa) post-thaw is experimental. In pubertal boys, the main option for fertility preservation is masturbation and cryopreservation of the ejaculate. Assisted ejaculation using penile vibratory stimulation or electroejaculation and surgical sperm retrieval can be used in a sequential manner after failed masturbation. Physicians should inform boys and parents about the gonadotoxic effects of cancer treatment and offer fertility preservation. Preclinical experience has identified challenges in pre-pubertal fertility preservation, but available options are expected to be successful when today’s pre-pubertal boys with cancer become adults. By contrast, fertility preservation in pubertal boys is clinically proven and should be offered to all patients undergoing cancer treatment.
Yazarlar (11)
1
Christian F.S. Jensen
ORCID: 0000-0002-7810-1413
2
Lihua Dong
3
Murat Gul
ORCID: 0000-0002-6657-6227
4
Mikkel Fode
ORCID: 0000-0002-8963-4581
5
Simone Hildorf
ORCID: 0000-0002-6639-0625
6
Jorgen Thorup
7
Eva Hoffmann
8
Dina Cortes
9
Jens Fedder
ORCID: 0000-0001-5383-5501
10
Claus Y. Andersen
11
Jens Sønksen
Kurumlar
Copenhagen University Hospital
Copenhagen Denmark
Det Sundhedsvidenskabelige Fakultet
Copenhagen Denmark
Gentofte Hospital
Hellerup Denmark
Københavns Universitet
Copenhagen Denmark
Odense Universitetshospital
Odense Denmark
Rigshospitalet
Copenhagen Denmark
Selçuk Üniversitesi
Selçuklu Turkey
Syddansk Universitet
Odense Denmark
Metrikler
26
Atıf
11
Yazar