Scopus
YÖKSİS Eşleşti
Current and emerging treatment options for premature ejaculation
Nature Reviews Urology · Kasım 2022
YÖKSİS Kayıtları
Current and emerging treatment options for premature ejaculation
Nature Reviews Urology · 2022 SSCI
DOÇENT MURAT GÜL →
Makale Bilgileri
DergiNature Reviews Urology
Yayın TarihiKasım 2022
Cilt / Sayfa19 · 659-680
Scopus ID2-s2.0-85137056426
Özet
Premature ejaculation (PE) is a prevalent male sexual dysfunction. Current standard treatment regimens include behavioural therapies, topical anaesthetics, dapoxetine and other selective serotonin reuptake inhibitors (SSRIs). Most of the pharmacotherapeutic options target neurotransmitters (such as serotonin and oxytocin) that have a role in the ejaculation mechanism. However, these treatments are mildly effective and only provide a temporary delay in the ejaculation latency time, and PE recurs when the treatment is stopped. Thus, a treatment for PE is urgently needed and research is ongoing to find the ideal PE therapy. The efficacy and safety of topical anaesthetics and SSRIs in delaying ejaculation have been confirmed in many well-designed controlled trials. Both preclinical and clinical studies on new-generation SSRIs are ongoing. Moreover, promising results came from clinical trials in which the efficacy of on-demand PE therapies targeting neurotransmitters other than serotonin, such as α1-adrenoceptor antagonists and oxytocin antagonists, was assessed. Surgical intervention and neuromodulation have been proposed as potential treatment options for PE; however, current PE guidelines do not recommend these treatments owing to safety concerns.
Yazarlar (3)
1
Murat Gul
ORCID: 0000-0002-6657-6227
2
Kadir Böcü
3
Ege Can Şerefoǧlu
Kurumlar
Biruni Üniversitesi
Istanbul Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Silopi State Hospital
Sirnak Turkey
Metrikler
33
Atıf
3
Yazar