Scopus
Synthesis, analgesic, and anti-inflammatory activities of [6-(3,5-dimethyl-4-chloropyrazole-1-yl)-3(2H)-pyridazinon-2-yl]acetamides
Archives of Pharmacal Research · Mayıs 2005
Makale Bilgileri
DergiArchives of Pharmacal Research
Yayın TarihiMayıs 2005
Cilt / Sayfa28 · 509-517
Scopus ID2-s2.0-23844457999
Özet
A series of structurally diverse amide derivatives of [6-(3,5-dimethyl-4- chloro-pyrazole-1-yl)-3(2H)-pyridazinone-2-yl]acetic acid were prepared and tested for their in vivo analgesic and anti-inflammatory activity by using p-benzoquinone-induced writhing test and carrageenan-induced hind paw edema model, respectively. The analgesic and anti-inflammatory activity of the compounds, 7c, 7d and 7k were found to be equipotent to aspirin (as an analgesic) and indometacin (as an anti-inflammatory drug), respectively. The other amide derivatives generally resulted in lower activity on comparision with reference compounds.
Yazarlar (7)
1
Murat Süküroglu
2
Burcu Çaliskan Ergün
3
Serdar Ünlü
4
Mustafa Şahin
5
Esra Küpeli
6
Erdem Yesilada
7
Erden Banoǧlu
Anahtar Kelimeler
Analgesic
Anti-inflammatory
Carrageenan
Pyrazole
Pyridazinone
Writhing
Kurumlar
Gazi Üniversitesi
Ankara Turkey
Metrikler
58
Atıf
7
Yazar
6
Anahtar Kelime